罗汉果甜苷对肝纤维化大鼠肝组织病理学和细胞的影响  

Effects of mogroside on hepatic histopathology and liver cells in rats with hepatic fibrosis

作　　者：陈湘芸[1] 廖长秀[2] 宋开娟[1] 薛强[2] 肖刚[2] 黄岑汉[2] 

机构地区：[1]广西中医药大学,广西南宁530001 [2]右江民族医学院,广西百色533000

出　　处：《右江民族医学院学报》2013年第6期771-773,共3页Journal of Youjiang Medical University for Nationalities

基　　金：广西科学研究与技术开发计划课题(项目编号:0992003A-12和0898001);广西自然科学基金(项目编号:2013GXNSFBA019197)

摘　　要：目的研究罗汉果甜苷对复合因素所致肝纤维化病理组织改变及肝脏主要细胞肝细胞和肝星状细胞的影响。方法通过给予大鼠高脂、乙醇和四氯化碳三种因素建立复合因素所致肝纤维化模型,观察罗汉果甜苷对肝纤维化大鼠肝脏病理组织学、肝星状细胞活化标志α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)表达和肝细胞凋亡的影响。结果不同剂量罗汉果甜苷对肝组织纤维化病变有一定程度的改善作用,可抑制肝脏α-SMA表达,减少肝细胞凋亡的作用。结论罗汉果甜苷对肝纤维化大鼠肝星状细胞活化和肝细胞凋亡有一定的抑制作用,可能为其抗纤维化的机制之一。Abstract： Objective To study the effects of mogroside on hepatic with multi hepatotoxic factor induced hepatic fibrosis. Methods Rats were treated with highfat, etha nol, and carbon tetraehloride to establish hepatic fibrosis models. Hepatic histopathology, the expression of smooth muscle actin （SMA, a marker of hepatic stellate cell activation） and hepatocyte apoptosis were observed to study the effects of mogroside on rats with hepatic fibrosis. Results The iniury of hepatic histo pathology in hepatic fibrosis was improved to a certain extent by treatment with different doses of mogroside. The expression of aSMA was inhibited and the hepatocyte apoptosis reduced in hepatic fibrosis by mogro side. Conclusion The inhibition of mogroside on hepatic stellate cell activation and hepatocyte apoptosis maybe one of its antifibrosis mechanisms.

关 键 词：罗汉果甜苷 肝组织病理学 肝细胞 

分 类 号：R285.5[医药卫生—中药学]