Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia  

作　　者：YANG Xiaobo YUAN Zuyi CAO Hongmei MA Xiancang 

机构地区：[1]Department of Psychiatry, the First affiliated Hospital, Medical School of Xi'an Jiaotong University

出　　处：《Journal of Medical Colleges of PLA(China)》2013年第6期368-372,共5页中国人民解放军军医大学学报（英文版）

基　　金：Supported by the Natural Science Foundation of Shaanxi Province(2011JM4008)

摘　　要：Objective： To investigate the effect of ziprasidone on QTc in Chinese patients with schizophrenia. Methods： The study involved 27 patients with schizophrenia. Ziprasidone was initiated with 40 mg/day. From day 3 to day 7, the dose was increased gradually to 120-160 mg/d according to the effectiveness and tolerahility. QTc values were measured at the beginning and month 6. Results： At the beginning of the 6 months treatment, the mean QTc interval of patients was （387.5±19.0） ms. At the end of the study, it was （402.9±23.6） ms. The difference has statistically significance （P〈0.05）. The mean QTc interval changed significantly throughout 6-months period but no one exceed the QTc dangerous limits. Significant correlation was found between QTc interval and the dose. Conclusion： In summary, our results suggest that ziprasidone has good tolerance in patient with schizophrenia despite its dose-related QTc prolongation. Ziprasidone have no pro-arrhythmic profileObjective: To investigate the effect of ziprasidone on QTc in Chinese patients with schizophrenia. Methods: The study involved 27 patients with schizophrenia. Ziprasidone was initiated with 40 mg/day. From day 3 to day 7, the dose was increased gradually to 120-160 mg/d according to the effectiveness and tolerability. QTc values were measured at the beginning and month 6. Results: At the beginning of the 6 months treatment, the mean QTc interval of patients was(387.5±19.0) ms. At the end of the study, it was(402.9±23.6) ms. The difference has statistically significance(P<0.05). The mean QTc interval changed significantly throughout 6-months period but no one exceed the QTc dangerous limits. Significant correlation was found between QTc interval and the dose. Conclusion: In summary, our results suggest that ziprasidone has good tolerance in patient with schizophrenia despite its dose-related QTc prolongation. Ziprasidone have no pro-arrhythmic profile.

关 键 词：QTC ZIPRASIDONE SCHIZOPHRENIA 

分 类 号：R742.3[医药卫生—神经病学与精神病学]