14-3-3ζ、S100A8在膀胱癌中的表达及与膀胱癌侵袭和迁移的关系  

The expressions of 14-3-3ζ and S100A8 in bladder carcinoma and their relation to invasion and metastasis in bladder cancer

作　　者：陈宇[1,2] 宋永胜[1] 

机构地区：[1]中国医科大学附属盛京医院泌尿外科,辽宁沈阳110000 [2]解放军第二0二医院泌尿外科,辽宁沈阳110000

出　　处：《现代肿瘤医学》2014年第1期106-109,共4页Journal of Modern Oncology

基　　金：沈阳市科技计划项目(编号:F11-264-1-64)

摘　　要：目的:观察膀胱癌组织中14-3-3ζ、S100A8的表达变化,分析其与膀胱癌侵袭和迁移关系,并探讨其临床意义。方法:免疫组织化学法检测90例膀胱癌组织及癌旁组织中14-3-3ζ、S100A8的表达。图像分析技术分析两个指标在膀胱癌中的阳性表达率,并分析其与临床分期、病理分级的关系。结果:膀胱癌组织中14-3-3ζ、S100A8的阳性表达率为65.56%、54.44%,癌旁正常组织中分别为10%、0%,与癌旁正常组织相比,癌组织中的阳性表达率差异均有统计学意义(P<0.05)。14-3-3ζ、S100A8的表达均与膀胱癌的分化程度、临床分期、淋巴结迁移、复发性等有关(P<0.05)。结论:14-3-3ζ、S100A8在膀胱癌组织中异常表达与膀胱癌的侵袭和迁移有高度相关性。14-3-3ζ、S100A8检测可以有效应用于膀胱癌的检测、预后判断。Objective：To investigate the expressions of 14-3-3ζ,S100A8 in bladder cancer tissues,and to explore the correlation of thier expressions with the invasion and metastasis of bladder cancer and the clinical significance.Methods：The expressions of 14-3-3ζ,S100A8 in bladder cancer were assessed by immunohistochemistry and the positive rates were calculated by image analysis,and the correlation with clinicopathological factors were analyzed.Results：The positive rates of expressions of 14-3-3ζ,S100A8 were 65.56%,54.44% in bladder cancer tissues,and they were 10%,0% in normal tissues.Contrasted with normal tissues,the expressions of 14-3-3ζ and S100A8 were up-regulated（P〈0.05）.The expressions of 14-3-3ζ and S100A8 correlated with the clinical stage,the differentiation degree of cancer of the bladder,lymphatic metastasis and recurrence.Conclusion：The abnormal expression of 14-3-3ζ and S100A8 might play a certain role in invasion and metastasis of bladder cancer.14-3-3ζ and S100A8 would be used as a molecular maker for detecting bladder cancer and its recurrence.

关 键 词：14-3-3ζ S100A8 膀胱癌 侵袭与迁移 

分 类 号：R737.14[医药卫生—肿瘤]