前列腺癌组织p27及Survivin表达的临床意义  

Clinical significance of the expressions of p27,Survivin in prostate cancer

作　　者：王超奇[1] 余大海[1] 王金花[2] 田玉英[2] 梁姗[2] 梁静[2] 王璠[1] 王明[1] 

机构地区：[1]内蒙古民族大学附属医院泌尿外科,内蒙古通辽028007 [2]内蒙古民族大学附属医院病理科,内蒙古通辽028007

出　　处：《现代肿瘤医学》2014年第1期123-125,共3页Journal of Modern Oncology

基　　金：内蒙古自治区高等学校科学技术研究项目(编号:NJZY13173)

摘　　要：目的:研究凋亡相关蛋白p27、Survivin在前列腺癌(PCa)中的表达及相关性。方法:应用免疫组织化学方法检测68例前列腺癌组织和47例前列腺增生组织p27、Survivin蛋白的表达。结果:前列腺癌组织中p27、Survivin蛋白的阳性表达率分别为38.2%(26/68)、67.6%(46/68),前列腺增生组织中分别为80.9%(38/47)、0(0/47),p27和Survivin蛋白阳性表达率在前列腺癌组织和前列腺增生组织中差异具有统计学意义(P<0.01)。p27和Survivin蛋白表达与前列腺癌病理分级、临床分期和转移情况具有相关性(P<0.05),前列腺癌组织中Survivin与p27的表达呈负相关(P<0.01)。结论:联合检测p27和Survivin蛋白,有助于对进展性前列腺癌细胞的侵袭力作出正确评价。Objective：To study the expressions of p27, Survivin and their correlation in prostate cancer（PCa）. Methods： Immunohistochemistry was employed to measure the expression of p27 and Survivin in 68 cases of prostatic cancer and 47 cases of benign prostatic hyperplasia. Results： In prostatic cancer tissue, the positive expression rates of p27 and Survivin were 38.2% （26/68）and 67.6% （46/68）. In benign prostatic hyperplasia tissue, the positive ex- pression rates of p27 and Survivin were 80.9% （38/47） ,0 （0/47）. The positive expression of p27 and Survivin between prostatic cancer and benign prostatic hyperplasia were significantly different（ P 〈 0.01 ）. The positive expression of p27 and Survivin were related with the histologic grade, clinical stage and metastasis of prostatic cancer（ P 〈0.05）. The expression of Survivin had a reverse correlation with p27 expression in prostatic cancer（P 〈 0.01 ）. Conclusion：The detection of p27 and Survivin protein in PCa may help to evaluate the degree of cell apoptosis.

关 键 词：前列腺癌 P27 SURVIVIN 

分 类 号：R737.25[医药卫生—肿瘤]