宫颈微偏腺癌25例临床病理分析  

A clinicopathological study of minimal deviation adenocarcinoma of the uterine cervix

作　　者：伊喜苓[1,2] 朱连成[1] 林蓓[1] 高蔼峰 赵薇[3] 张宇华[4] 李妍[5] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]沈阳市妇婴医院,辽宁沈阳110011 [3]中国医科大学附属盛京医院病理科,辽宁沈阳110004 [4]辽宁省肿瘤医院妇瘤科,辽宁沈阳110000 [5]沈阳市妇女儿童保健中心,辽宁沈阳110032

出　　处：《现代肿瘤医学》2014年第1期157-160,共4页Journal of Modern Oncology

基　　金：辽宁省科技攻关项目(编号:2003225004-2;2005225007-2);沈阳市科技攻关项目(编号:1053125-1-54-1)

摘　　要：目的:探讨宫颈微偏腺癌(MDA)的临床及病理形态学特点、组织化学特征,以期提高疾病的早期诊断与治疗。方法:对三家医院10年内的25例宫颈微偏腺癌的临床资料、病理形态学、免疫组织化学等资料进行回顾性分析。结果:临床主要表现为阴道水样或黏液样排液和不规则流血,宫颈桶状肥大、质硬。病理特征为浸润宫颈深部肌层的大量黏液腺体,腺体浸润深部血管及神经组织。免疫组化:p53(+),Ki-67>50%(-),CA125(-),AB(pH 2.5)/PAS(+)。结论:宫颈微偏腺癌的诊断应结合临床,凡有阴道流水样排液和不规则流血,宫颈增粗变硬,宫颈活检怀疑宫颈MDA者,应做宫颈锥形切除活检,及时确诊,早期治疗。Objective：To investigate the clinical,pathological and immunohistochemical features of minimal deviation adenocarcinoma（MDA） of the uterine cervix in order to improve the early diagnosis and treatment of the disease.Methods：The clinical pathological features were retrospectively reviewed by conducting a retrospective study of 25 cases consecutively treated in three institutes over a 10 years period.Results：The main clinical manifestations were vaginal watery or mucoid discharge and irregular bleeding.Signs were cervical hypertrophy or thickening.The pahotlogical features are massive muscoid glands invade cervical deep muscularis and vessles,or even nervous tissue.Immunohistochemical staining features are p53（＋）,Ki-67 〉50%（-）,CA125（-）,AB（pH 2.5）/PAS（＋）.Conclusions：For early stage diagnoses,MDA should be considered when cervical hypertrophy is present in patients complaining of a vaginal profuse watery or mucoid discharge and irregular bleeding.Early application of cervical biopsy and conization is important to early dignosis and treatment.

关 键 词：宫颈肿瘤 微偏腺癌 诊断 鉴别诊断 

分 类 号：R737.33[医药卫生—肿瘤]