垂体原发性淋巴瘤1例并文献复习  

Primary pituitary lymphoma:one case report and literature review

作　　者：刘坦坦[1] 张兆祥[2] 李昂[3] 杨守京[1] 

机构地区：[1]第四军医大学西京医院病理科,陕西西安710032 [2]第四军医大学西京医院整形外科,陕西西安710032 [3]第四军医大学,陕西西安710032

出　　处：《现代肿瘤医学》2014年第1期166-168,共3页Journal of Modern Oncology

摘　　要：目的:报道1例原发于垂体的罕见的弥漫大B细胞淋巴瘤并结合文献探讨其临床病理特点、诊断和鉴别诊断。方法:对1例垂体原发性弥漫大B细胞淋巴瘤进行常规HE染色及免疫组化染色,分析其组织学特点及免疫表型。结果:镜下肿瘤由排列呈片状的小至中等大小的细胞构成,于蝶窦黏膜内弥漫性生长。瘤细胞形态较一致,圆形,核大、深染,异型性明显,染色质粗块状,核分裂多见,胞浆稀少。免疫表型:肿瘤细胞LCA、CD20、CD79α弥漫阳性,CD99弱阳性,FSH、LH、ACTH、GH、Pro、TSH、AE1/AE3、EMA、CD3、CD45RO、CD117、PLAP均阴性,Ki-67显示肿瘤细胞增殖指数约80%。结论:垂体原发性淋巴瘤(PPL)是一种非常罕见的恶性肿瘤,诊断和鉴别诊断主要依赖病理形态学特点和免疫表型。Objective：To report one case of primary pituitary lymphoma（PPL） and discuss its clinicopathological features, diagnosis and differential diagnosis by analyzing related articles. Methods：Routine H＆E（ Hematoxylin ＆ Eosin） and immunohistochemical staining were performed on the specimen. Results：Histologically, this tumor, diffusely involving the sphenoid sinus mucosa and pituitary gland, was composed a monomorphic proliferation of small - to medium - sized lymphocytes characterized by scant eosinophilic cytoplasm,irregularly rounded nucleus, and a high level of mitotic activity. Immunohistochemically, LCA, CD20 and CD79α were diffusely positive in the tumor cells, while other markers（ FSH, LH, ACTH, GH, Pro, TSH, AE1/AE3, EMA, CD3, CD45RO, CD117, PLAP） were negative. The labeling index of Ki -67 to the tumor cells was 80%. Conclusion：PPL is a rare malignant disease, mainly diagnosed by the characteristics of morphology and immunotype.

关 键 词：弥漫大B细胞淋巴瘤 垂体 诊断 鉴别诊断 

分 类 号：R736.4[医药卫生—肿瘤]