Caveolin-1在消化系统肿瘤中的研究进展  

Research advancement of Caveolin-1 in digestive system tumors

作　　者：张坤东 黄陈[1] 裘正军[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海市胰腺疾病重点实验室,上海交通大学胰腺癌诊治中心

出　　处：《现代肿瘤医学》2014年第1期223-226,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81101844;812101080 27);上海市人才发展资金项目(编号:2012040);上海市浦江人才计划项目(编号:13PJD024);上海交通大学晨星青年学者项目

摘　　要：细胞窖蛋白-1(Caveolin-1)为分子量21-24kD的膜蛋白,是Caveolae的主要结构成分,参与胆固醇运输、囊泡转运,细胞信号转导等过程,同时与肿瘤的发生、发展和转移密切相关。本文介绍Caveolin-1的结构和功能以及在肿瘤中的作用,重点综述Caveolin-1在消化系统肿瘤的表达及其临床意义,并展望Caveolin-1在消化系统肿瘤中的应用前景。The 21 -24kD membrane molecule, Caveolin - 1 is a major structural component of Caveolae. Caveolin - 1 is involved in diverse cellular processes ranging from cholesterol homeostasis and vesicular transport to signal transduction. Caveolin - 1 is also closely related to cancer pathogenesis, development and metastasis. This review aims to recommend the characteristics and functions of Caveolin - 1 and its roles in tumor development. Caveolin - 1 expression and clinical significance in digestive system tumors was reviewed mainly. Finally, the application prospect of Caveolin - 1 in digestive system tumors was viewed.

关 键 词：细胞窖蛋白-1 恶性肿瘤 消化系统肿瘤 

分 类 号：R730.1[医药卫生—肿瘤]