腺苷A_(2B)受体在心血管系统研究新进展  

Recent research progress of adenosine A_(2B) receptor in cardiovascular system

作　　者：易云[1] 高云[1] 

机构地区：[1]南昌大学基础医学院生理学教研室,江西南昌330006

出　　处：《中国药理学通报》2014年第1期21-24,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81100829;81360136);江西省青年科学家培养计划(2010)

摘　　要：腺苷(adenosine)是人体内的一种重要的生物活性物质,它主要有4种受体亚型A1、A2A、A2B和A3。在心血管系统研究中,发现腺苷A2B受体激活可产生多种生理和病理效应。腺苷A2B受体在血管舒张、炎症因子生成、氧自由基释放、血小板的聚集、血管新生、心肌缺血、心肌纤维化等方面有着重要作用,有可能成为心血管系统疾病治疗的靶点。Adenosine is a kind of important bioactive substances in the body, it mainly has four kinds of receptor subtypes A1 , A2A, A2B and A3. In cardiovascular system, it＇ s found that the activation of adenosine A2B receptor can produce a variety of physiological and pathological effects. In vasodilatation, genera- tion of proinflammatory factor, oxygen free radicals release,platelet aggregation, angiogenesis, myocardial ischemia, myo- cardial fibrosis and so on, adenosine A2R receptor may play an important role, and is likely to become a treatment target for the diseases of the cardiovascular system.

关 键 词：腺苷 A2B受体 氧自由基 血管新生 心肌缺血 心肌纤维化 

分 类 号：R-05[医药卫生] R392.11