脑卒中患者血浆中α-突触核蛋白及其寡聚体形成量变化的研究  

Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke

作　　者：陈予东[1,2] 尹娜[1,2] 李昕[1,2] 杨巍巍[1,2] 李旭冉[1,2] 于顺[1,2] 

机构地区：[1]首都医科大学宣武医院神经生物学研究室,教育部神经变性病重点实验室,北京100053 [2]北京市老年病医疗研究中心分子诊断实验室,北京100053

出　　处：《首都医科大学学报》2013年第6期826-829,共4页Journal of Capital Medical University

基　　金：国家自然科学基金(81071014);国家重点基础发展计划(973)计划(2011CB504101);首都卫生发展科研专项课题(首发2011-1001-01);国家科技支撑计划课题(2012BAI10B03);北京市自然科学基金(7102076)~~

摘　　要：目的探讨脑卒中患者血浆中α-突触核蛋白(α-synuclein,α-Syn)含量的变化,以及血浆对α-Syn寡聚体形成的影响。方法收集2012年3月至5月首都医科大学宣武医院神经科诊断为脑卒中的住院患者50例,另收集年龄和性别与之相匹配的30例健康人群为对照组。用ELISA法检测各组人群血浆中的α-Syn总量及寡聚体形成量。结果脑卒中患者血浆α-Syn总含量及寡聚体形成量较对照组均有显著增加。结论脑卒中患者血浆中α-Syn含量增高增强其寡聚体的形成。Objective To explore the changes of a-synuclein（a-Syn） level in plasma of patients with stroke, and observe the effect of plasma on the formation of oligomeric α-Syn. Methods A total of 50 hospitalized patients with stroke were recruited, they were diagnosed by neurologist of Xuanwu Hospital, Capital Medical University from March to May in 2012. A total of 30 people were recruited as the control group. ELISA was used to evaluate the total α-Syn and the formation of α-Syn oligomers in different groups. Results α- Syn oiigomeric formation and total α-Syn level in the plasma of stroke patients was higher than that in controls＇. Conclusion Plasma from stroke patients contained high level of total α-Syn and the plasma enhanced formation of oligomeric α-Syn.

关 键 词：Α-突触核蛋白 脑卒中 血浆 

分 类 号：R742.5[医药卫生—神经病学与精神病学]