K_v3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达  

Expression of K_V3.4 in Oral Lichen Planus and Oral Squamous Cell Carcinoma

作　　者：缪克红[1] 聂敏海[2] 宋成成[2] 宋萍萍[2] 伍宝琴[2] 

机构地区：[1]自贡市第一人民医院口腔科,四川自贡643000 [2]泸州医学院附属口腔医院口腔内科,四川泸州640000

出　　处：《口腔颌面外科杂志》2013年第6期420-423,共4页Journal of Oral and Maxillofacial Surgery

摘　　要：目的:研究钾离子通道蛋白kv3.4在正常口腔黏膜(normal oral mucosa,NOM)、口腔扁平苔藓(oral lichen planus,OLP)、口腔鳞状细胞癌(squamous cell carcinoma,OSCC)中的表达及意义。方法:免疫组织化学技术检测16例NOM、20例OLP和30例OSCC组织中kv3.4的表达,采用Wilcoxon秩和检验,α=0.05。结果:kv3.4在OSCC中的表达强度高于OLP(P<0.05),kv3.4在OLP组织的表达高于正常组织(P<0.05),且糜烂型OLP中的表达高于非糜烂型OLP(P<0.05),差异均具有统计学意义。结论:kv3.4可能与OLP及OSCC的发生、发展有一定的关系。Objective： To study the various expression of Kv3.4 in normal oral mucosa （NOM）, oral lichen planus （OLP）, and oral squamous cell carcinoma （OSCC）. Methods： 20 OLP specimens, 30 OSCC surgical resection specimens and 16 NOM cases were collected and were immunohistochemically studied by SP methods. Results： The expressions of Kv3.4 were more intensive in OLP and OSCC than in NOM tissues （P〈0.05）; The expression of Kv3.4 was higher in OSCC than in OLP tissues （P〈0.05）. Conclusions： Kv 3.4 may be served as a new marker in the differential diagnosis of oral lichen planus and oral squamous cell carcinoma.

关 键 词：口腔扁平苔藓 口腔鳞状细胞癌 KV 3 4 

分 类 号：R739.85[医药卫生—肿瘤]