口腔颗粒细胞瘤13例临床病理观察  

Oral granular cell tumor: a clinicopathological analysis of 13 cases

作　　者：袁晓红[1] 王凤光[1] 汪育苗[1] 刘晓勇[1] 

机构地区：[1]首都医科大学口腔医学院病理科,北京100050

出　　处：《北京口腔医学》2013年第6期341-344,共4页Beijing Journal of Stomatology

摘　　要：目的回顾性分析口腔颗粒细胞瘤的临床特征、组织病理学特征、诊断要点,并检测肿瘤细胞增殖活性。方法收集存档资料13例,分析其临床特征及组织病理学特征并随访,应用免疫组化方法行S-100、CD68及Ki-67染色。结果本组病例中有11例发生在舌部,S-100及CD68染色阳性,少数肿瘤细胞Ki-67阳性。形态学上肿瘤细胞有时与横纹肌肌纤维难以区分,肿瘤表面的鳞状上皮有时呈假上皮瘤样增生。结论口腔颗粒细胞瘤大多数为良性,具有较低的增殖活性。伴有假上皮瘤样增生的病例要仔细观察,避免误诊。Objective To analyse the clinical and histopathological features of oral granular cell tumor（OGCT）. Methods Clinical and histopathological features were assessed in 13 patients with OGCT. Immunohistochemical staining for S-100, CD68 and Ki-67 was conducted. Results Eleven cases of OGCT in this study occurred in tongue. Immunohistochemical analysis showed that 100% of granular cells had moderate or strong staining of S-100 and CD68. A small number of tumor cells expressed Ki-67. On occasion OGCT cells were hardly distinguished with striated muscle fiber, and squamous cells on the surface of OGCT in some cases showed pseudo-epitheliomatous hyperplasia. Conclusion The majority of OGCT are benign and have lower proliferation activity. The cases with pseudo- epitheliomatous hyperplasia should be observed carefully to avoid misdiagnosis.

关 键 词：口腔颗粒细胞瘤 免疫组织化学 假上皮瘤样增生 

分 类 号：R739.8[医药卫生—肿瘤]