以基底节为参照的淋巴瘤患者脑FDG代谢减低的PET/CT评估  

Evaluation of Brain FDG Uptake in Patients with Lymphoma Lesions Using Basal Ganglia as Reference

作　　者：张清波[1] 黄庆娟[1] 陈建伟[1] 

机构地区：[1]南京医科大学第一附属医院PET/CT中心

出　　处：《中国医学计算机成像杂志》2013年第6期540-544,共5页Chinese Computed Medical Imaging

摘　　要：目的:利用PET/CT计算非霍奇金淋巴瘤患者大脑皮质与基底节18F-FDG平均摄取比值,建立以基底节为参照的淋巴瘤患者大脑皮质FDG摄取变化的检测方法。方法:回顾性分析经病理证实未经治疗的非中枢神经系统高FDG代谢非霍奇金淋巴瘤患者55例,其中19例经治疗好转后复检;健康体检人士30例。在全脑PET/CT图像上,计算大脑皮质/同侧基底节的平均SUV比值,淋巴瘤组与对照组比较,复检病例治疗前后比较。结果:治疗前淋巴瘤患者大脑半球皮质与同侧基底节平均SUV比值显著低于对照组(P<0.001)。19例治疗后好转的病例,治疗后显著高于治疗前(P<0.02)。结论:高FDG代谢的非霍奇金淋巴瘤可导致大脑皮质葡萄糖摄取减低,经治疗好转后大脑皮质糖代谢可恢复,以基底节FDG代谢为参照的比值可以相对量化并监测淋巴瘤病程中脑组织葡萄糖代谢的变化。Purpose： To investigate whether basal ganglia can work as reference for measuring changes of cerebral cortical FDG uptake in patients with non-Hodgkin＇ s lymphoma lesions. Methods： Fifty-five patients with histologically confirmed non-Hodgkin＇ s lymphoma without treatment were undergone FDG PET/CT exam. Nineteen of them who were improved after treatment were re-examined with PET/CT. Thirty healthy subjects were included as control for comparison. PET/CT examinations were retrospectively reviewed. The volumetric regions of interest （drawn by freehand drawing software） were placed over cerebral cortex and basal ganglia （head of caudate nucleus and lenticular nucleus） respectively by referring to CT and PET/CT fusion images to measure mean standardized uptake value （SUV ）. The SUV was measured in the cerebral cortex and basal ganglia. The ratios of SUVmean in the bilateral cerebral cortex and that in the ipsilateral basal ganglia were calculated and analyzed in all cases. Results： In pre-treatment patients, the ratios of SUV in the bilateral cerebral cortex and that in the ipsilateral basal ganglia were 0.74±0.07 （left） and 0.74±0.07 （right）. Meanwhile, in control subjects, the ratios were 0.91±0.06 （left） and 0.90±0.05 （right）. The ratios of SUV in patients were significantly lower than those in control subjects （t-7.706, P〈0.01 in left; t-4.932, P〈0.02 in right）. For patients with improved conditions after effective treatment, the ratios were 0.87±0.05 （left） and 0.89±0.04 （right）, which were significantly higher than those of pre-treatment, which were 0.78±0.03 （left） and 0.78±0.04 （right） （t=6.532, P〈0.01 in left; t=2.916, P〈0.02 in right）. Conclusion： High FDG metabolized non-Hopkin＇ s lymphoma may lead to reduction of cortical glucose uptake （diversion of FDG from the brain to the lymphoma tissue）, which may be reversed with the effective therapy of lymphoma. Taking basal ganglia as the reference, the changes of brain glucose

关 键 词：PET 18F-FDG 脑摄取 基底节 淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]