三种抗青光眼药物对选择性激光小梁成形术疗效的影响  

Effects of three glaucoma medications on the efficacy of selective laser trabeculoplasty

作　　者：唐敏[1] 傅扬[1] 富名水[1] 樊莹[1] 郑志[1] 孙晓东[1] 许迅[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,上海市200080

出　　处：《眼科新进展》2014年第1期54-57,共4页Recent Advances in Ophthalmology

基　　金：上海市卫生局课题基金资助项目(编号:20114118)~~

摘　　要：目的分析单独局部使用β受体阻滞剂、α受体激动剂或前列腺素类滴眼液是否影响高眼压症或原发性开角型青光眼患者接受选择性激光小梁成形术(selective laser trabeculoplasty,SLT)的疗效。方法前瞻性分析2009年6月至2011年7月上海交通大学附属第一人民医院眼科收治的患者73例(73眼)。其中药物组52例(包括分别单独使用β受体阻滞剂21例、α受体激动剂14例、前列腺素类药物17例),对照组21例;所有患者接受全周(360°)SLT治疗并随访观察6个月。将眼压降幅≥20%判定为治疗有效。结果治疗后2周、1个月、3个月和6个月药物组整体与对照组眼压值组间差异均无统计学意义(t值分别为-0.222、-0.651、-0.549和-1.153,P值分别为0.825、0.517、0.585和0.253);分别单独使用β受体阻滞剂、α受体激动剂或前列腺素类药物的患者之间眼压值差异均无统计学意义(F值分别为1.010、0.650、0.170和0.950,P值分别为0.371、0.527、0.847和0.396。各观察期药物组整体与对照组治疗有效率组间差异均无统计学意义(χ2值分别为0.041、0.020、0.478和0.262,P值分别为0.839、0.886、0.489和0.609);分别单独使用β受体阻滞剂、α受体激动剂或前列腺素类药物的患者之间治疗有效率差异无统计学意义(治疗后2周有效率采用Fisher’s确切概率法(双侧),P值为1.000,治疗后1个月、3个月和6个月采用卡方检验,χ2值分别为0.904、1.169和0.343,P值分别为0.636、0.557和0.843)。结论单独局部使用β受体阻滞剂、α受体激动剂或前列腺素类抗青光眼药物对SLT的疗效没有影响。Objective To analyze the effects of topical β-antagonist,α-agonist or prostaglandin analogue single use on the efficacy of selective laser trabeculoplasty （SLT） for patients with intraocular hypertension or primary open-angle glaucoma. Methods This prospective clinical study totally included 73 patients （73 eyes） with intraocular hypertension or primary open-angle glaucoma from the Depamnent of Oph thalmology, Shanghai Jiaotong University affiliated First People＇ s Hospital during June 2009 to July 2011 ,in which 52 cases （ including 21 cases using topical β-antagonist,14 cases using α-agonist and 17 cases using prostaglandin analogue ） were in drug group and 21 cases were in control group. All patients received SLT over 350° of the trabecular meshwork and followed up for 5 months. Intraocular pressure （IOP） reduction 20% or more was defined as effective therapy. Results At 2 weeks, 1 month,3 months and 5 months after treatment, there was no statistical difference between the total drug group and control group in IOP（t = -0. 222, -0.651, -0. 549, - 1. 153;P =0. 825,0. 517, 0. 585,0. 253 ）. There was also no statistical difference among those patients using topi cal β-antagonist, ^-agonist or prostaglandin analogue（F= 1. 010,0. 650,0. 170,0.95 ;P = 0. 371,0.527,0. 847,0. 395）. At different follow-up time points,there was no statistical difference between the total drug group and control group in effective rates（x~ = 0. 041, 0. 020,0.478,0. 262 ;P = 0. 839,0. 886,0. 489,0. 609 ）. There was also no statistical difference among those patients using topical p-antagonist, c^-agonist or prostaglandin analogue （ Fisher＇ s Exact Test at 2 weeks, P = 1. 000 ,X2 test at 1 month, 3 months and 6 months,x2 = 0. 904,1. 169,0. 343,P = 0. 636,0. 557,0. 843 ）, Conclusion Topi- cal [^-antagonist, c^-agonist or prostaglandin analogue single use has no effect on the efficacy of SLT.

关 键 词：青光眼 选择性激光小梁成形术 眼压 

分 类 号：R775.2[医药卫生—眼科]