基于量子点标记探针技术的肿瘤分子分型研究进展  

Research progress on the molecular classification of tumors by quantum dot-based nanotechnology

作　　者：方敏[1] 彭春伟[1] 陈创[2] 庞代文[3] 李雁[1] 

机构地区：[1]武汉大学中南医院肿瘤科,湖北省医学临床研究中心,肿瘤生物学行为湖北省重点实验室,武汉市430071 [2]武汉大学人民医院乳腺甲状腺外科 [3]武汉大学化学与分子科学学院

出　　处：《中国肿瘤临床》2014年第1期37-41,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金面上项目(编号:81171396)、重点项目(编号:81230031/H18);国家科技重大专项(编号:2012ZX10002012-12)资助~~

摘　　要：恶性肿瘤在分子水平上具有高度异质性,是个体化治疗的依据。发展同时显示肿瘤原位多分子指标的技术对研究肿瘤生物学行为至关重要。量子点标记探针技术因其具有独特的光学和化学特性,在肿瘤诊断、监测、治疗、发病机制、分子分型及异质性研究中均有广阔应用前景。本文总结该技术在肿瘤分子分型方面的应用进展。Malignant tumors are highly heterogeneous in terms of molecular phenotypes such that personalized therapy will be- come the standard for tumor therapy. Molecular classifications of cancer based on differences in biological behavior are important for selecting treatment strategies and prognostication. The unique optical and chemical properties of quantum dots have been widely used in biomedical applications such as tumor diagnosis, monitoring, pathogenesis, treatment, molecular pathology, and heterogeneity based on biological markers. In this study, we discuss the application of quantum dot-based nanotechnology and the molecular classification of cancer in personalized oncology.

关 键 词：量子点 肿瘤 分子分型 多色成像 

分 类 号：R730.4[医药卫生—肿瘤]