移植早期卵裂胚胎对促性腺激素释放激素拮抗剂方案结局影响分析  

Effect of transplanting human early-cleavage embryo on pregnancy outcomes in GnRH antagonist protocols

作　　者：贺平[1] 刘海鹏[1] 彭姝明[1] 陈艺[1] 杨帆[1] 

机构地区：[1]湖南省郴州市第一人民医院生殖医学中心,郴州423000

出　　处：《生殖医学杂志》2014年第1期20-23,共4页Journal of Reproductive Medicine

摘　　要：目的探讨早期卵裂(EC)作为胚胎质量预测指标对于促性腺激素释放激素拈抗剂(GnRH-ant)方案体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法回顾性分析了2011年1月至2013年6月在本中心共213例应用GnRH-ant方案IVF/卵胞浆内单精子注射(ICSI)-ET治疗的患者。按是否移植早期卵裂胚胎将患者分为A组(全部移植早期卵裂胚胎)、B组(混合移植胚胎)和C组(全部移植晚期卵裂胚胎)。分别比较这些患者的临床资料和妊娠结局。结果 GnRH-ant方案IVF/ICSI-ET各组的临床妊娠率、胚胎种植率并无显著性差异(P>0.05)。结论在GnRH-ant方案IVF/ICSI-ET中早期卵裂并不能作为胚胎种植潜能的预测指标,对其治疗结局无显著影响。Objective： To explore the effect of transplanting human early-cleavage embryo on pregnancy outcomes in GnRH antagonist protocols Methods： A retrospective study was conducted in IVF/ICSI-ET cycles with GnRH antagonist protocols in our reproductive center from January 2011 to July 2013. A total of 213 patients were included in the study and divided into three groups： group A （all the transferred embryos were early-cleavage embryos）, group B（the transferred embryos were early-cleavage and late-cleavage embryos）and group C（all the transferred embryos were late-cleavage embryos）. The basic clinical data, oocyte and embryo conditions,and pregnancy outcome were compared among three groups. Results： The clinica[ pregnancy rate and embryo implantation rate were not significantly different among the three groups in the IVF/ICSI-ET cycles with GnRH antagonist protocols （P〉0. 05）. Conclusions： Early cleavage of zygote is not a reliable predictor for embryo implantation potential in the GnRH antagonist protocols.

关 键 词：早期卵裂 GnRH—ant方案 体外受精-胚胎移植 

分 类 号：R[医药卫生]