高白细胞性白血病患者细胞分离治疗及端粒酶检测  

LEUKAPHERESIS AND TELOMERASE TEST IN ACUTE LEUKEMIC PATIENTS WITH HYPERLEUKOCYTOSIS

作　　者：李昕权[1] 范炜[2] 阎安文 邓春江[1] 

机构地区：[1]军事医学科学院附属医院,北京100039 [2]解放军第359医院,江苏镇江212001

出　　处：《白血病》2000年第6期338-340,共3页

摘　　要：目的 :分析高白细胞性白血病细胞分离术治疗及端粒酶检测的临床价值。方法 :用血细胞分离机 ,对12例高白细胞性急性白血病患者进行白细胞分离治疗 ,并用端粒重复扩增法检测分离细胞和骨髓细胞端粒酶活性。结果 :经白细胞分离术后 ,10 / 12例患者临床症状减轻 ,白细胞计数降低至 5 0× 10 9/ L 以下 ,得以继续顺利化疗 ;患者伴有较高的端粒酶活性 ,其中 6 / 10例临床缓解时仍较高 ,且化疗治疗效果差。结论 :白细胞分离术可有效减轻白血病的细胞负荷 ,避免肿瘤细胞溶解综合征 ;高白细胞性白血病患者伴有较高端粒酶活性的生物特征需进一步研究。Objective:To evaluate the clinical value of leukapheresis and telomerase test in acute leukemic patients with hyperleukocytosis.Methods:The leukapheresis with running blood cell separator and the telomeric repeat amplification proticol (TRAP).Results: The clinical symptoms of patients ameliorate and the leukocyte count reduce below 50×10 9/L after leukapheresis.No tumor lysis syndrome appear when chemotherapy were administered. Strong telomerase activity were observed in initial and remission stages in campany with poor clinical course especially in the cases with chromosome abnormalities.Conclusion:The leukapheresis could decrease effectively tumor loads and leukostatic sludging without acute tumor lysis syndrome.The character of higher telomerase activity in acute leukemic patients with hyperleukocytosis remain to be investigated.

关 键 词：白血病 高白细胞 端粒酶 白细胞分离术 治疗 

分 类 号：R733.7[医药卫生—肿瘤]