IFRD1基因rs3807213位点基因多态性与胃癌关系的研究  

Relationship of IFRD1-rs3807213 Gene Polymorphism with the Risk of Gastric Cancer among Chinese

作　　者：彭昌兵[1] 徐锐[1] 肖硕萌[2] 庄文[1] 

机构地区：[1]四川大学华西医院胃肠外科中心,成都610041 [2]四川省肿瘤医院胃肠外科,成都610047

出　　处：《四川大学学报（医学版）》2014年第1期49-52,共4页Journal of Sichuan University(Medical Sciences)

基　　金：四川省科技厅科技支撑项目(No.2010SZ0179)资助

摘　　要：目的探讨干扰素相关发育调节蛋白1（IFRDl）基因rs3807213位点基因多态性与中国汉族人胃癌发生的关系。方法采用病例一对照研究方法，以53例胃癌患者为病例组，50例健康人为对照组。采集外周血，提取全血DNA，再采用聚合酶链反应（polymerase chain reaction，PCR）扩增DNA后，对IFRDl基因rs3807213位点进行测序，分析3个基因型（AA，AC，CC）在病例组和对照组之间的分布差异，并研究其与胃癌风险及临床病理分期的关系。结果病例组内rs3807213位点C等位基因频率高于对照组（OR值为3．759，95％CI为1．521～9．294；P=0．003）。与对照组相比，胃癌患者具有更高频率的rs3807213位点CC基因型（OR值为4．028，95％CI为1．513～10．720；P=0．004）。将病例组按病理分期进行分组分析，rs3807213位点各基因型及等位基因频率的组间差异均无统计学意义（P〉0．05）。结论IFRDl基因rs3807213位点基因多态性可能与中国汉族人胃癌发生有关，但与胃癌的病理分期无关。Objective To investigate the association between rs3807213 gene polymorphism in interferon- related developmental regulator 1 gene（ IFRD1） and the risk of gastric cancer among Chinese. Methods There were 53 gastric cancer patients and 50 healthy people included in this case-control study. The blood samples were collected from each observed object and genotype （AA,AC, CC） of IFRDX rs3807213 SNP was detected after polymerase chain reaction （PCR）. The relationshipvs of rs3807213 gene polymorphism with gastric cancer risk,clinic and pathologic features were analyzed. Results Patients with stomach cancer had a significantly higher frequency of rs3807213 C allele distributions （OR = 3.759,95%CI=1. 521-9. 294;P=0.003） than the controls. Compared with control group,patients with gastric cancer had a significantly higher frequency of rs3807213 CC genotype（OR= 028,95%CI=1.513-10.720;P=0.004）. When stratified by pathological stage of gastric cancer, there was no significant difference observed. Conclusion IFRD1-rs3807213 polymorphism may be associated with the increased risk of gastric cancer.

关 键 词：胃癌 干扰素相关发育调节蛋白1 基因多态性 

分 类 号：R735.2[医药卫生—肿瘤]