还原型谷胱甘肽联合腺苷蛋氨酸治疗化疗药物性肝损害的临床疗效  

Clinical efficacy of liver lesion with the treatment of reduced glutathione and ademetionine

作　　者：时兆燕 汪伟民[1] 邓松华[3] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,合肥230022 [2]安徽省蚌埠市第三人民医院干部内科,蚌埠233000 [3]安徽医科大学病理生理学教研室,合肥230032

出　　处：《安徽医科大学学报》2014年第1期122-124,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学重点科研项目(编号:KJ2010A177)

摘　　要：回顾性分析还原型谷胱甘肽(GSH)联合腺苷蛋氨酸治疗化疗药物引起肝损害的临床疗效。83例化疗患者随机分为联合组(n=43)和对照组(n=40),在预防性保肝药物应用基础上,对照组予GSH 180 mg静滴1次/d,联合组在对照组基础上加用腺苷蛋氨酸1.0 g静滴1次/d。两组疗程12 d。联合组较对照组疗效更佳,联合组总有效率95.35%,明显高于对照组80.00%(P<0.05)。联合腺苷蛋氨酸治疗化疗药物性肝损害临床疗效肯定,优于单用。Clinical efficacy of liver lesion with the treatment of reduced glutathione and ademetionine was analyzed retrospectively. 83 patients were randomly divided into two groups based on the application of preventive hepatoprotective drug. Control group was treated with reduced glutathione intravenous drip infusion once a day （n = 40）, while treatment group with reduced glutathione and ademetionine （Transmetil） once a day （n = 43）. After 12 days, the clinical efficacy of treatment group was better than that of control group. Total response rate was 95.35% for treatment group, much better than that of control group（80.00% ）. There was significant difference between two groups （ P 〈 0. 05 ）. Reduced glutathione and ademetionine are more effective in the treatment of chemotherapeuticsinduced liver lesion than only with reduced glutathione.

关 键 词：还原型谷胱甘肽 腺苷蛋氨酸 化疗药物性肝损害 恶性肿瘤 

分 类 号：R575.3[医药卫生—消化系统]