表皮生长因子基因多态性与食管癌易感性的关系  

Association of epidermal growth factor genetic polymorphisms and susceptibility to esophageal cancer

作　　者：王旭[1] 尹俊[1] 顾海勇[1] 陈锁成[1] 

机构地区：[1]江苏大学附属人民医院心胸外科,212002

出　　处：《江苏医药》2014年第1期21-23,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(81101889)

摘　　要：目的研究中国汉族人群表皮生长因子(EGF)基因多态性与食管癌发病风险的关系。方法采用以医院为基础的病例-对照研究,SNPscanTM高通量基因分型技术分析380例食管癌(食管癌组)和380例非肿瘤患者(对照组)EGF rs3756261T>C和EGF rs11568835G>A基因多态性,计算各种基因型的食管癌发病风险及其95%可信区间(CI)。结果两组EGF rs3756261T>C和EGF rs11568835G>A多态性位点基因频率无明显差异。Logistic回归显示,相对于EGF rs3756261TT基因型,CC等位基因型与食管癌的发病风险无明显相关(调整OR=0.89,95%CI=0.45-1.76);在隐性模型中,相对于TT+TC基因型,CC基因型与食管癌的发病风险无统计学意义的相关性(OR=0.90,95%CI=0.46-1.75)。对EGF rs11568835G>A位点进行相同的Logistic回归分析,也没有发现其与食管癌的发病风险存在统计学关联性。结论 EGF rs3756261T>C和EGF rs11568835G>A基因多态性可能与食管癌易感性无关。Objective To investigate the association of epidermal growth factor（EGF） genetic polymorphisms with the susceptibility to esophageal cancer in Chinese Han population. Methods The genetic polymorphisms of EGF rs3756261T）C and EGF rs11568835G〉A were determined by a custom-by-design 2x48-Plex SNPscanWMKit in a case-controlled study of 380 esophageal cancer cases （group A） and 380 cancer-free controls（group C）. Results There was no significant difference in genotype distribution frequency of two single nucleotide polymorphisms between two groups. Logistic regression analysis showed that EGF rs3756261CC genotype might not be associated with the susceptibility to esophageal cancer compared with its wild-type homozygote（adjusted OR=0.89,95% CI=0. 45-1.76）. EGF rs11568835G）A variant genotype was not associated with the susceptibility to esophageal cancer as well. Conclusion EGF rs3756261T^C and EGF rsl1568835G〉A genetic polymorphisms might not be associated with the risk for esophageal cancer in Chinese Han population.

关 键 词：表皮生长因子 单核苷酸多态性 食管癌 

分 类 号：R735[医药卫生—肿瘤]