肺癌患者6种血清肿瘤标志物检测结果分析  

An analysis of six kinds of serum tumor markers detection in patients with lung cancer

作　　者：郭柳薇[1,2] 高兴华[1,3] 黄王莹[1,2] 

机构地区：[1]广西医科大学第七附属医院 [2]梧州市工人医院检验科,543001 [3]梧州市工人医院呼吸科,543001

出　　处：《江苏医药》2014年第1期69-71,共3页Jiangsu Medical Journal

摘　　要：目的探讨6种血清肿瘤标志物联合检测在肺癌中的诊断价值。方法对86例肺癌患者(肺癌组)及50例良性肺疾病患者(对照组)进行糖类抗原125(CA-125)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)、细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、鳞状上皮细胞癌相关抗原(SCC)检测。结果肺癌组CA-125、CA19-9、CEA、SCC、Cyfra21-1、NSE值明显高于对照组(P<0.05)。非小细胞癌患者CA-125、CA19-9值高于小细胞癌患者(P<0.05),CEA、NSE低于小细胞癌患者(P<0.05);鳞癌患者CA-125、SCC值高于腺癌患者(P<0.05),CA19-9、CEA值低于腺癌患者(P<0.05)。6种肿瘤标志物联合检测的诊断灵敏度为94.19%,特异度为84.00%;单项检测指标中灵敏度最高的是CA-125,特异度最高的是Cyfra21-1。结论对肺癌患者进行多种血清肿瘤标志物检测能明显提高肺癌的诊断灵敏度。Objective To investigate the prognostic value of detecting 6 kinds serum tumor markers in lung cancer. Methods Serum tumor markers of carbohydrate antigen 125 （CA-125） and carbohydrate antigen 19-9 （CA19-9）, carcinoma embryo antigen （CEA）, cell keratin 19 pieces （Cyfra21-1）, neuron specific enolase （NSE）, enzyme-related squamous cell carcinoma antigen （SCC） were detected in 86 patients with lung cancer（group A） and 50 patients with benign lung disease （group C）. Results Serum levels of CA19-9, CA-125, CEA, SCC, Cyfra21-1 and NSE were higher in group A than those in group C（P〈0. 05）. Serum levels of CA-125 and CA19-9 were higher, but CEA and NSE were lower, in patients with small cell carcinoma than those in patients with non-small cell carcinoma（P%0. 05）. Serum levels of CA-125 and SCC were higher, but CA19-9 and CEA were lower, in patients with squamous cell carcinoma than those in patients with adenoearcinoma （P〈0. 05）. Combined detection of 6 kinds of tumor markers showed a sensitivity of 94.19% and specificity of 84. 00% in the diagnosis of lung cancer. When a single tumor marker was detected, CA-125 had the highest sensitivity and Cyfra21-1 had the highest specificity. Conclusion Multiple serum tumor markers detections can improve the sensitivity in the diagnosis of lung cancer.

关 键 词：肺癌 肿瘤标志物 

分 类 号：R734[医药卫生—肿瘤]