老年精神分裂症和Alzheimer病性痴呆患者的认知功能与脑电地形图检查的相关性研究  

Study on the Relationship between Cognitive Functions and Brain Electrical Activity Mapping in Elderly Patiants with Schizophrenia and Alzheimer Dementia

作　　者：谭小林[1] 赵科[1] 陈仲新[2] 曹国兴[1] 文晏[1] 李远[1] 程雪[1] 黄杰[1] 周成东[2] 周建初[1] 

机构地区：[1]重庆市精神卫生中心老年一科,中国重庆401147 [2]重庆市精神卫生中心医技科,中国重庆401147

出　　处：《国际老年医学杂志》2014年第1期1-5,18,共6页International Journal of Geriatrics

基　　金：重庆市卫生局医学科研项目计划（2011-2-401）

摘　　要：目的：探讨老年精神分裂症和Alzheimer病性痴呆患者认知功能与脑电地形图检查的相关性.方法：50例老年精神分裂症患者（SS）、50例Alzheimer病性痴呆患者（AD）和52名健康老年人（NC）依次完成脑电地形图检查（BEAM）、简易智力状态检查（MMSE）、威斯康星卡片分类测验（WCST）、临床记忆量表（CMS）、连线测验（TMT-A）、数字符号（DSy）及数字广度（DSp）测验.结果：①SS组认知功能与8个脑区的18个BEAM指标显著相关,AD组与6个部位（前额部、前中后颞区、中央及顶部）的9个BEAM指标显著相关,NC组则与8个脑区的31个BEAM指标显著相关.②SS组及NC组均有8个BEAM变量进入以MMSE为因变量的回归方程,SS组的决定系数明显大于NC组（R2=0.637,R2=0.363）,AD组仅有2个变量进入以MMSE为因变量的回归方程,且决定系数最低（R2=0.222）.③右侧额部（F4）β波功率、左中央部（C3）δ波功率、左中颞部（T3）β波功率分别对SS患者、AD患者及正常老人MMSE的回归贡献最大,且有统计学意义（P〈0.01）.结论：SS的认知功能与BEAM检查的相关范围介于NC与AD之间,其相关强度大于NC及AD;BEAM-EEG结合NPT检查对于SS和AD有重要的鉴别诊断价值.OBJECTIVE： To investigate the relation between cognitive functions and Brain Electrical Activity Mapping （BEAM） in elderly patients with Schizophrenia （SS） and Alzheimer dementia （AD）. METHOD： 50 patients with SS, 50 patients with AD and 52 elderly with normal control （NC） were investigated by BEAM and neuropsychological tests in detail, mini - mental state exam- ination （MMSE）, wisconsin card sorting test （WCST）, clinical memory scale （CMS）, trail making test- A （TMT- A）, digital symbol （DSy） and digit span （DSp） test. RESULTS： ①In SS group the cognitive function was significantly associated with 18 inde- xes of BEAM in 8 brain regions. In AD group the cognitive function was significantly associated with 9 indexes of BEAM in 6 brain re-gions which was namely forehead, anterior temporal region, middle temporal region, posterior temporal region, central and top. In NC group the cognitive function was significantly associated with 31 indexes of BEAM in 8 brain regions. ②In SS group and NC group there were 8 BEAM variables into the regression equation which dependent variable was MMSE, and the coefficient of determination of SS group was significantly greater than that in NC group （R2 = 0. 637 vs. R2 = 0. 363）. In AD group, there were 2 BEAM variables into the regression equation which dependent variable was MMSE, and the coefficient of determination was the least （R2 = 0. 222）. ③The β wave power in the right frontal （F4）, the 8 wave power in the left central portion （ C3 ） and the β wave power in the left middle temporal （T3） had the largest contribution to the regression in SS, AD and NC patients. And there were significantly statisti- cal difference （P 〈0. 01 ）. CONCLUSIONS： The relation range between cognitive function and BEAM checks in SS patients was be- tween NC and AD patients, and the relation strength in SS patients was greater than that in NC and AD patients. BEAM - EEG exami- nation combined with neuropsychological tests h

关 键 词：老年精神分裂症 Alzheimer病性痴呆 认知功能 神经心理测验 脑电地形图 

分 类 号：R749.16[医药卫生—神经病学与精神病学]