肝血管平滑肌脂肪瘤的临床病理特征及微血管密度的改变观察  

Clinicopathological analysis of angiogenesis in hepatic angiomyolipoma

作　　者：田海英[1] 陆新元[1] 朱玉瑶 丛文铭[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院病理科,上海200438

出　　处：《中国现代医学杂志》2013年第32期66-69,共4页China Journal of Modern Medicine

基　　金：第二军医大学干细胞与医学研究中心研究生创新实验课题(No:CMRC1203)

摘　　要：目的探讨肝血管平滑肌脂肪瘤(HAML)的临床病理特征及其与微血管密度(MVD)改变之间的关系。方法复习34例HAML的临床资料和病理切片,选取典型病变蜡块进行相关标记物免疫组织化学染色,检测指标包括HMB45、平滑肌肌动蛋白(SMA)、CD34、β-catenin、Hep Par1、CK18、CK19,单位面积内CD34阳性血管数作为MVD,并结合HAML的病理特征进行分析。结果 34例HAML中HMB45和CD34均呈弥漫性阳性表达,32例SMA表达阳性,5例β-catenin表达阳性,其余标志物如Hep Par1、CK18、CK19均为阴性。CD34在HAML组织中呈散在窦隙状阳性表达,在瘤旁肝组织的门管区散在弱阳性表达。MVD的改变与肿瘤的大小密切相关,肿瘤大于5 cm者显著高于肿瘤小于5 cm者(P<0.01),与瘤旁肝组织相比,肿瘤中的MVD显著升高(P<0.01)。结论 MVD增加可能是HAML增殖活性提高的相关病理学基础。[Objective] To investigate the clinicopathologic features and microvessel density in hepatic, and analyze the relationship of them. [Methods] The clinicopathologic features of 34 HAML were retrospec tively analyzed. Tumor tissue block was selected for the immunohistochemical staining in all cases with anti- bodies include HMB45, SMA, CD34, β-catenin, Hep Par 1, CK18 and CK19. Quantitation of sinusoid-like vessels was performed and analyzed with the pathological features of HAML. [Results] IHC results were： HMB45 （34/34）, SMA （32/34）, CD34 （34/34）, β-catenin （5/34）, all cases were negative for Hep Par 1, CK18 and CK19. HAML present a sinusoid pattern of enthelia cell differentiation, in normal livers, CD34 staining was confined to small vessels in the portal area. MVD was correlated to the tumor size, the MVD of tumors more than 5 cm in diameter was significance higher than that of tumors with a diameter of less than 5 cm. Intratumoral MVD were higher than those in the non-tumorous liver tissue. [Conclusion] The increase of MVD may be related to the HAML proliferative activity.

关 键 词：肝脏 血管平滑肌脂肪瘤 临床病理特征 微血管密度 

分 类 号：R365[医药卫生—病理学] R575[医药卫生—基础医学]