外周血内皮组细胞与脑梗死患者预后的相关性  

Correlation between peripheral blood endothelial progenitor cells and prognostic outcome of patients with acute ischemic stroke

作　　者：路敬叶[1] 何龙锦[1] 周汝娟[1] 

机构地区：[1]江苏省泰兴市人民医院神经内科,225400

出　　处：《蚌埠医学院学报》2013年第12期1573-1575,1578,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨脑梗死患者发病早期外周血内皮祖细胞(endothelial progenitor cells,EPCs)与预后的关系。方法:以CD133和CD34标记的双阳性细胞作为EPCs,用流式细胞仪对108例急性(发病48 h)脑梗死患者(脑梗死组)、98例脑血管危险因素患者(危险因素组)、40名健康志愿者(对照组)的外周血EPCs进行计数检测。分别对脑梗死组发病48 h、梗死后21 d、梗死后90 d进行美国国立卫生研究院卒中量表评分(NIHSS)。结果:脑梗死组、危险因素组外周血EPCs均明显低于对照组(P<0.01)。脑梗死组EPCs亦明显高于危险因素组(P<0.01)。NIHSS≥12分组较<12分组的外周血EPCs明显降低(P<0.01)。急性期外周血高水平的EPCs与脑梗死后21 d NIHSS改善程度(≥4分)密切相关(P<0.01),与脑梗死后90 d的良好预后独立相关(P<0.01)。结论:脑梗死患者急性期外周血EPCs可作为脑梗死预后的一个独立预测指标。Objective：To investigate the influence of peripheral blood endothelial progenitor cells （EPCs） on the prognostic outcome of patients with acute ischemie stroke（IS）. Methods：The peripheral blood EPCs（double-stained markers：CD133/CD34） of 108 patients who had suffered from IS within 48 hours（ stroke group） ,98 risk patients for cerebrovascular diseases（ risk factor group） and 40 healthy volunteers（ control group） were determined by flow cytometry. Meanwhile, the National Institutes of Health stroke scale （NIHSS） was used to evaluate the physical function and neurological impairment of the patients at the acute（48 hours）, convalescence（21 days） and chronic phases of the stroke（90 days）. Results：The circulating EPCs level in the stroke group and the risk factor group was remarkably lower than that of the control（P 〈 0.01 ） ;patients with NIHSS ≥ 12 had significantly lower level of EPCs than those with NIHSS 〈 12 （P 〈 0.01 ）. High number of peripheral blood EPCs was closely associated with the improvement of NIHSS（ ≥4 ） on day 21 after IS（ P 〈 0.01 ）and independently associated with the good outcome on day 90 after IS （P 〈 0.01 ）. Conclusions： The number of peripheral blood EPCs may act as an independently predictive maker for the prognosis of patients after IS.

关 键 词：脑梗死 内皮祖细胞 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]