VEGF和MVD在大肠癌中的表达及预后意义  

Expressions of VEGF,MVD in colorectal carcinoma and its prognostic significance

作　　者：骆礼波[1] 程家平[2] 杨伟明[1] 杨雪峰[2] 石磊[1] 贺新媛[1] 刘勤[1] 苏晓玥 任宇[1] 

机构地区：[1]遵义医学院附属医院甲状腺乳腺外科,贵州遵义563099 [2]遵义医学院附属医院胃肠外科,贵州遵义563099

出　　处：《遵义医学院学报》2013年第6期546-549,共4页Journal of Zunyi Medical University

基　　金：遵义医学院附属医院中青年科研启动基金资助项目(NO:201005)

摘　　要：目的 探讨血管内皮生长因子（vascular Endothelial Growth Factor VEGF）和微血管密度（Microvessel Density MVD）在大肠癌组织中的表达与患者生存预后关系.方法 收集1997～2007年收治生存期≥5年及≤3年大肠癌患者标本各30例,应用免疫组织化学（Envision）测定这60例大肠癌组织中VEGF和MVD表达,分析检测结果与临床病理特点及患者预后关系.结果 ≥5年30例大肠癌患者VEGF,MVD表达强度与≤3年30例大肠癌患者在浸润深度,TNM分期,淋巴结转移间比较,均有显著性差异（P＜0.001）,而性别,年龄,分化程度及病理分型差异性不显著（P＞0.05）,且VEGF与MVD表达两者呈正相关（r=0.974,,P＜0.05）.结论 VEGF对大肠癌的生长和浸润转移有促进作用,VEGF和MVD可以作为判断大肠癌患者预后重要参考指标.Objective Objective To explore the expression of Vascular Endothelial Growth Factor （VEGF） and Microvessel Density （MVD） in colorectal carcinoma and their prognostic significance. Methods The coloreetal cancer specimens from the patients who had been operated in our hospital over a past 10 - year period were collected, with 30 cases of either survival time 〉5 years or 〈3 years. Immu-nohistochemical technique （Envision） was used to detect the expression of VEGF and MVD in the 60 cases of colorectal carcinoma, The relationship of their expression with clinico - pathological features and prognosis of colorectal carcinoma was analyzed. Results In 5 years （30 cases） of patients with colo- rectal cancer, VEGF and MVD expression were less than 3 years （less 30 cases） patients with colorectal cancer. The invasion depth of embellish, TNM stage, and lymph node metastasis had significant differ- ence than 5 year - patients （P 〈 0. 001 ）. Thegender, age, and degree of differentiation and pathologi-cal stages were not significantly different （P 〉 0.05）. VEGF and MVD expression were positively corre-lated with prognosis （ r = 0.974 P 〈 0.05 ）. Conclusion VEGF promotes growth, invasion and metastasis of coloreetal carcinoma. VEGF expression or MVD may be one of the important predictors for the prog-nostic marker of human colorectal carcinoma.

关 键 词：大肠癌 VEGF MVD 预后 

分 类 号：R735.4[医药卫生—肿瘤]