番茄红素改善缺血再灌注模型大鼠认知功能损伤  

Lycopene Improves Cognitive Function in Ischemia-Reperfusion Rat Models

作　　者：李祥[1] 王波[1] 金鑫[2] 李国术 何平平[4] 唐艳艳[5] 张敏[5] 李金凤[5] 欧阳新平[5] 

机构地区：[1]南华大学附属第一医院麻醉科,湖南衡阳421001 [2]南华大学附属南华医院妇产科 [3]衡阳市中心医院急诊科 [4]南华大学护理学院 [5]南华大学医学院生理学教研室

出　　处：《中南医学科学杂志》2013年第6期559-561,共3页Medical Science Journal of Central South China

基　　金：湖南省科技厅资助项目(2013FJ3027);湖南省教育厅资助项目(13B103);衡阳市科技局课题(2012KJ22)

摘　　要：目的检测番茄红素(LP)对大脑中动脉栓塞(MCAO)所致缺血再灌注模型大鼠认知功能的影响。方法制备MCAO模型大鼠,使用Morris水迷宫及Y迷宫实验检测LP对模型大鼠认知功能的影响。结果 MCAO术后大鼠水迷宫平均游泳速度显著下降,Y迷宫学会逃避电击所需训练次数显著增加。LP低剂量及高剂量大鼠与模型组大鼠比较,水迷宫平均游泳速度显著增加,Y迷宫学会逃避电击所需训练次数显著减少。结论番茄红素改善缺血再灌注模型大鼠的认知功能损伤。Objective To examine effects of Lycopene（LP）on cognitive function in ischemia-reperfusion rat models caused by middle cerebral artery obstruction（MCAO）. Methods MCAO rat models were set up and effects of LP were detected on cognitive function in rat models with Morris water maze and Y maze test. Results Average swimming speed of rats in water maze dropped significantly after MCAO, required training numbers need for avoiding electric shock in Y maze increased significantly. Compared with model group rats, average swimming speed of rats in water maze in low dose LP and high dose LP group increased significantly, training numbers need for avoiding electric shock in Y maze in low dose LP and high dose LP group decreased significantly. Conclusion Lycopene improves cognitive function in ischemia-reperfusion rat models.

关 键 词：番茄红素 创伤性脑外伤 缺血再灌注模型 认知 

分 类 号：R965[医药卫生—药理学]