阿托伐他汀对急性脑梗死患者CRP的影响  

Effect of atorvastatin on serum CRP in patients with acute cerebral infarction

作　　者：王国军[1] 

机构地区：[1]江苏常熟市第一人民医院神经内科,常熟215500

出　　处：《中国实用神经疾病杂志》2013年第23期43-44,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察降脂药物阿托伐他汀对急性脑梗死患者的疗效,以探讨他汀类降脂药物治疗急性脑梗死的作用机制。方法 162例患者以随机数字法随机分为2组,观察组采用阿托伐他汀口服治疗,对照组采用依达拉奉注射治疗,21d后比较2组疗效、血脂和CRP变化情况。结果观察组有效率82.72%,对照组76.54%,2组比较差异有统计学意义(Ridit Z=10.378,P<0.0001);治疗21d后,观察组TC、TG、LDL和CRP 4个指标与治疗前相比均降低,差异有统计学意义(P<0.05);对照组TC、TG和CRP 3个指标与治疗前相比均降低,差异有统计学意义(P<0.05),LDL与治疗前相比差异无统计学意义(P>0.05);2组TC、TG、LDL和CRP 4个指标比较差异均有统计学意义(P<0.05)。结论阿托伐他汀可以改善患者血脂水平,降低C反应蛋白含量,对急性脑梗死具有显著疗效。Objective To observe the curative effect of atorvastatin on patients with acute cerebral infarction, and to explore the mechanisms. Methods Totally 162 patients were divided into 2 groups randomly, and the observation group received oral atorvastatin treatment, the control group received edaravone injection treatment. After 21 days, the changes of blood lipid and CRP between the two groups were compared. Results After treatment, the efficacy rate in the observation group was 82.72%, with 76.54% in the control group, the observation group was significantly better than the control group （Z= 10. 378, P〈0. 0001）. After treatment, TC, TG, LDL and CRP of the observation group was lower in than that before treatment （P〈0.05） ; TC, TG and CRP of the control group was lower than that before treatment （P〈0.05）, while LDL of the control group had no significant difference with that of before treatment （P〉0.05）; TC, TG, LDL and CRP after treatment had statistically significance between two groups （P〈0.05）. Conclusion Atorvastatin can improve the blood lipid, reducing C reactive protein, and have obvious curative effect on acute cerebral infarction.

关 键 词：阿托伐他汀 急性脑梗死 C反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]