藤三七对高脂血症模型大鼠的降血脂作用  

Effect of Anredera Cordfolia (Ten) Steenis on Decreasing Blood Lipid in Rat Models with Hyperlipidemia

作　　者：吕纪华[1] 王丽[1] 邓聿胤[1] 刘瑛[1] 饶伟源[1] 蒋珍藕[1] 

机构地区：[1]广西中医药研究院,广西南宁530022

出　　处：《中医药导报》2013年第12期93-94,共2页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西卫生厅重点科研课题(重2010112)

摘　　要：目的:研究藤三七对高脂血症模型大鼠的降血脂作用。方法:采用高脂饲料喂养建立高脂血症大鼠模型,同时以低、中、高三个剂量藤三七灌胃,连续30 d,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:与模型组比较,藤三七中、高剂量组TC、TG明显降低(P<0.05或P<0.01),藤三七高剂量组HDL-C明显升高(P<0.05);藤三七中、高剂量组MDA含量明显降低(P<0.05),藤三七高剂量组SOD含量明显升高(P<0.05)。结论:藤三七对高脂血症大鼠具有降血脂作用,其作用机制可能与其提高机体抗氧化能力、减少脂质过氧化产物有关。Objective：To study the effect of Anredera Cordifolia （Ten） Steenis on blood lipid of rat models with hyperlipidemia.Methods：The hypedipidemia rat model was established by feeding with high-fat diet.At the same time the rats in treatment groups were intragastric administration respectively for 30 days.The levels of serum total cholesterol （TC）,triglyceride （TG）,high-density lipoprotein cholesterol （HDL-C）,superoxide dismutase （SOD） and malondialdehyde（MDA） were determined.Results：Compared with the model group,the levels of TC and TG were deceased significantly in high-and middle-dose groups of Anredera Cordifolia （Ten） Steenis（P＜0.05 or P＜0.01）.The level of HDL-C was increased significantly in high dose groups of A nredera Cordifolia （Ten） Steenis （P＜0.05）.The levels of MDA were deceased significantly in high-and middle-dose groups of Anredera Cordifolia（Ten） Steenis（P＜0.05）.The level of SOD was increased significantly in high dose groups of Anredera Cordifolia （Ten） Steenis （P＜0.05）.Conclusion：Anredera Cordifolia（Ten） Steenis can decrease the serum lipids of hyperlipidemic rats.Its functional mechanisms might lie in increasing the antioxidation of SOD and reducing MDA.

关 键 词：藤三七 高脂血症 降血脂 抗氧化 

分 类 号：R285.5[医药卫生—中药学]