CyclinA2基因5′-UTR多态性与结直肠癌遗传易感性的关系  

Association between CyclinA2 gene 5′-UTR polymorphism and genetic susceptibility of colorectal cancer

作　　者：王琦[1] 黄俊[1] 邱强[1] 黄明文[1] 周诚亮 

机构地区：[1]南昌大学第二附属医院胃肠外科,南昌330006 [2]江西省奉新县中医院普外科,奉新330700

出　　处：《重庆医学》2014年第1期64-66,共3页Chongqing medicine

摘　　要：目的：探讨CyclinA2基因5′-U T R区rs769236位点多态性与结直肠癌易感性的关系。方法采用病例-对照研究，收集150例结直肠癌患者及150例健康对照者，以聚合酶链反应-限制性片段长度多态性法（PCR-RFLP）检测CyclinA2基因rs769236位点单核苷酸多态性。rs769236多态性与结直肠癌发病风险的关系采用非条件logistic回归分析。结果与 rs769236 GG野生基因型相比，rs769236突变基因型（GA＋AA）携带者罹患结直肠癌的风险显著增高（校正 OR＝1．92，95％ CI＝1．10～3．36）。结论 CyclinA2基因rs769236多态性与CRC发病风险增高显著有关，突变基因型（GA＋AA）是人群罹患结直肠癌的独立危险因素。Objective To investigate the association between the rs769236 polymorphism at the 5′-UTR region of CyclinA2 gene and the susceptibility of colorectal cancer （CRC） .Methods A case-control study was carried out on the Chinese Han population , the rs769236 polymorphism of CyclinA2 were analyzed by PCR restriction fragment length polymorphism （PCR-RFLP）in 150 CRC cases and 150 healthy controls .The association between CRC risk and the SNP （rs769236） was estimated by an unconditional logis-tic regression model .Results Compared with GG wild genotype ,variant genotypes（GA＋AA） carriers had a significantly increased risk of CRC[adjusted odds ratio （OR）=1 .92 ,95% confidence interval（CI）=1 .10 -3 .36] .Conclusion The current results sug-gested that the SNP（rs769236） of CyclinA2 is significantly associated with the increased risk of CRC ,the variant genotypes（GA＋AA） are the independent risk factors of CRC in Chinese Han population .

关 键 词：结直肠癌 CyclinA2 单核苷酸多态性 

分 类 号：R735.3[医药卫生—肿瘤]