碳酸酐酶Ⅲ自身抗体在1型糖尿病人中的测定  

The detection of carbonic anhydrase III auto-antibody in patients with type 1 diabetes

作　　者：刘辰庚[1] 夏鸣 孟双[3] 王培昌[1] 

机构地区：[1]首都医科大学宣武医院检验科,北京100053 [2]上海闵行区中心医院检验科,上海201100 [3]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《临床和实验医学杂志》2014年第1期24-26,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨1型糖尿病(T1D)患者血清抗碳酸酐酶Ⅲ自身抗体水平的变化及其与抗氧化物、细胞因子之间的关系。方法选取T1D患者共368例(T1D组),另选取性别年龄匹配的健康受试者为对照组,测定其血清抗碳酸酐酶Ⅲ自身抗体、红细胞沉降率、超氧化物歧化酶(SOD)等4种抗氧化物和白细胞介素(IL)-2等4种细胞因子的水平。结果 T1D患者血清抗碳酸酐酶Ⅲ自身抗体水平显著高于健康对照组(P<0.05);T1D患者的SOD、谷胱甘肽过氧化物酶(GPx)和丙二醛(MDA)水平显著低于健康对照组(P<0.05);T1D患者的IL-2、IL-3和干扰素(IFN)-γ显著高于健康对照组(P<0.05)。结论抗氧化物和细胞因子水平的变化可能参与了T1D患者碳酸酐酶Ⅲ抗体的产生。Objective To determine the carbonic anhydrase Ⅲ auto - antibody, the level of cytokines and antioxidants in the patients with type 1 diabetes （T1D）. Methods Total 158 T1D patients were included into this study. The anhydrase Ⅲ auto -antibody, the level of 4 kinds of cytokines （IL-2, etc）, 6 kinds of antioxidants （SOD, etc） and erythrocyte sedimentation rate were detected in all these patients. Re- suits The levels of anhydrase Ⅲ auto - antibody, IL - 2, IL - 3 and IFN - T in T1D patients were significantly higher than that in control group （ P 〈0. 05）. The levels of SOD and GPx in T1D patients were significantly lower than that in control group （ P 〈0. 05 ）. Conclusion The change of the levels of cytokines and antioxidants may take part in the generation of carbonic anhydrase Ⅲ auto - antibody in T1D patients.

关 键 词：1型糖尿病 自身抗体 碳酸酐酶Ⅲ 细胞因子 抗氧化物 

分 类 号：R587.1[医药卫生—内分泌]