高危型HPV筛查联合液基细胞学检测在宫颈癌筛检中的应用价值  

High risk HPV screening combined with liquid based cytology analysis in cervical cancer screening

作　　者：李玉霞[1] 张燕[2] 

机构地区：[1]武汉市妇女儿童医疗保健中心妇产科,湖北武汉430014 [2]深圳市妇幼保健院妇科,广东深圳518000

出　　处：《海南医学院学报》2014年第2期223-225,共3页Journal of Hainan Medical University

基　　金：深圳市龙岗区科技计划项目(YS2011057)~~

摘　　要：目的:研究高危型人乳头瘤病毒(HPV)筛查与薄层液基细胞学(TCT)联合检测在宫颈癌及癌前病变筛查中的临床应用价值。方法:以418例育龄妇女为研究对象,分别行高危型HPV筛查、TCT检查及阴道镜下病理活检,以阴道镜下病理活检为"金标准",对高危型HPV筛查、TCT联检对宫颈癌及癌前病变筛查进行方法学评价。结果:418例高危型HPV阳性检出率为42.8%,随病变严重程度的加重,高危型HPV检出率升高;418例TCT检查结果:不典型鳞状细胞(ASC)以上病变检出率为51.4%,其中ASC 106例,低度鳞状上皮内病变(LSIL)70例,高度鳞状上皮内病变(HSIL)34例,鳞状细胞癌(SCC)5例;两种方法联检对宫颈上皮内瘤变(CIN)I以上病变的筛查相对于单独检查,灵敏度(92.3%)、约登指数(0.77)及阴性预测值(90.7%)均有不同程度的提高。结论:高危型HPV检查及TCT联检对宫颈癌的防治有重要的临床意义。Objective： To explore clinical application of high-risk human papillomavirus （HPV） screening, ThinPrep cytology test （TCT） and combined detection in screening of cervical cancer and pre- cancerous lesions. Methods： A total o{ 418 women at childbearing age were selected as the research object. They had high-risk HPV screening, TCT test and colposcopy biopsy. And colposcopy biopsy was consid- ered as ＂gold standard＂. Results： HPV positive rate was 42.8, and it was increased with the worsening lesion. TCT examination results showed that detection rate of lesion with level above atypical squamous cell （ASC） lesion was 51.4o//oo, including 106 ASC cases, 70 low squamous intraepithelial lesion cases, 34 high squamous intraepithelial lesion cases, 5 squamous cell carcinoma cases. In screening cervical intraepi

关 键 词：人乳头瘤病毒(HPV) 薄层液基细胞学(TCT) 宫颈癌 宫颈上皮内瘤变 病理学诊断 

分 类 号：R737.3[医药卫生—肿瘤]