肺癌患者预后与3-磷酸甘油醛脱氢酶高表达的关系  

Correlation between high expression of glyceraldehyde-3-phosphate dehydrogenase expression and prognosis in patients with lung cancer

作　　者：许世宁[1] 邹志强[1] 刘玉[1] 

机构地区：[1]济南军区总医院胸外科,250031

出　　处：《中华实验外科杂志》2014年第1期180-182,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨3-磷酸甘油醛脱氢酶（GAPDH）在肺癌中的表达及其意义.方法 应用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶（SP）法检测201例肺癌组织中GAPDH的表达,探讨其表达与临床病理特征及预后的关系.结果 GAPDH在鳞癌、腺癌、大细胞癌及小细胞癌中的表达率分别为81.3％、44.4％、64.7％、71.4％,组内比较差异有统计学意义（P＜0.01）.GAPDH表达与分化程度、淋巴结转移及TNM分期密切相关（P＜0.05）.Kaplan-Meier生存分析表明GAPDH表达、组织学类型、分化程度、淋巴结转移及TNM分期与肺癌患者的预后明显相关（P＜0.05）；Cox生存分析表明GAPDH表达、组织学类型、分化程度及TNM分期可作为肺癌患者预后评估的独立因素.结论 GAPDH表达与肺癌患者的预后密切相关.Objective To investigate the expression and prognostic significance of glyceraldehyde-3-phosphate dehydrogenase （GAPDH） in lung cancer.Methods Immunohistochemistry was used to detect GAPDH expression in 201 lung cancer tissues,and the relationship between GAPDH expression with clinieopathologic factors and prognosis was also assessed.Results The high-expression rate of GAPDH in squamous cell carcinoma,adenocarcinoma,lung large cell carcinoma and small cell lung cancer was 81.3%,44.4%,64.7% and 71.4%,respectively （P〈0.01）.GAPDH expression was closely correlated with differentiation,lymph node metastasis and TNM stage （P 〈0.05）.Kaplan-Meier univariate survival analysis revealed that GAPDH expression,histological type,differentiation,lymph node metastasis and TNM stage were related to the prognosis in lung cancer （P 〈 0.05）.Multivariate survival analysis showed that GAPDH expression,histological type,differentiation and TNM stages could be used as independent prognostic factors in lung cancer.Conclusion GAPDH expression is significantly associated with prognosis of patients with lung cancer.

关 键 词：3-磷酸甘油醛脱氢酶 肺肿瘤 预后 

分 类 号：R734.2[医药卫生—肿瘤]