精神分裂症患者血清特征多肽及其鉴定的研究  

Research on characteristic polypeptide and its identification in patient with schizophrenics

作　　者：程松[1] 郭婧澜[1] 丁银环[1] 王开正[1] 

机构地区：[1]泸州医学院附属医院检验科,四川泸州646000

出　　处：《检验医学与临床》2014年第1期1-2,5,共3页Laboratory Medicine and Clinic

基　　金：国家高技术研究发展计划(863计划)重点项目(2006AA02090407)

摘　　要：目的验证筛选出的具有特异性的血清蛋白标志物,为精神分裂症寻找客观的临床诊断依据。方法利用酶联免疫吸附试验(ELISA)技术和自动酶标仪分别测出血清特征多肽在精神疾病组和健康对照组中的吸光度值,再通过SPSS17.0对数据进行单因素方差分析,以此验证血清多肽的特异性。结果在单因素方差分析中,神经肽2在精神分裂症组与健康对照组比较,显著性水平为0.040,其他精神疾病对照组与健康对照组比较,显著性水平为0.008,说明神经肽2在这两组比较中差异有统计学意义(P<0.05);在多独立样本检验中,神经肽2的渐近显著性水平为0.031,神经肽2在各组之间的表达差异有统计学意义(P<0.05)。结论神经肽2在精神分裂症患者与健康人之间存在明显特异性,对该病诊断、治疗和基因的研究具有重要意义。Objective To verify the diagnosis basis of schizophrenia： Methods 646000, China） serum protein markers with the specificity for seeking the objective clinical The ELISA technique and the automatic enzyme standard instrument were adopted to measure the absorbance values of serum characteristic polypeptides in the mental disease group and the health control group,then the data were performed the one-way anova by SPSS17.0 in order to verify the specificity of the serum polypeptides. Results By the one-way anova,neuropeptide-2 had the significance level of 0, 040 in the comparison between the mental disease group and the healthy control group, the significance level was 0,008 in the comparison between the anxiety group aad the healthy control group,which indicated that neuropeptide-2 had signifi- cant difference in the：comparison of these two groups~ in the more independent sample test,the neuropeptide-2 as- ymptotic significance level was 0. 031, the expression of neuropeptides-2 had significant difference between the groups. Conclusion Neuropeptide 2 has obvious specificity between schizophrenia patients and normal people,which possesses the important Significance to the diagnosis, treatment and gene research of this disease.

关 键 词：精神分裂症 血清特征多肽 神经肽2 

分 类 号：R749.3[医药卫生—神经病学与精神病学]