影响盐酸维拉帕米脉冲释放片体外“时滞”的因素考察  

The factors influencing lag time of pulsed release tablet of verapamil in vitro

作　　者：邹豪[1] 蒋雪涛[1] 马伯良[2] 郭涛[3] 

机构地区：[1]第二军医大学药学院,上海200433 [2]吉林空军医院药剂科 [3]沈阳军区总医院药剂科

出　　处：《中国现代应用药学》2000年第6期450-453,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :考察影响盐酸维拉帕米脉冲片控时效果的因素。方法 :通过体外溶出的方法考察脉冲控释片的时滞 ,主要包括溶出条件和处方因素两方面。结果 :介质的酸碱度不影响制剂的控时效果 ;转速不影响制剂起崩时间 ,但对溶出速度有一定的影响 ;粘度越大的介质 ,释药时滞也越大。包衣用量增加、控时层中亲水性成分PEG 60 0 0含量减小、控时层中PEG类型的分子量的增加 ,均能使药物释放滞后时间明显增大 ;包衣颗粒大小对控时效果基本没有影响。结论 :溶出条件作用因素的考察为进一步的体内研究奠定了基础 ;OBJECTIVE:To investigate the factors that influence dissolution characters of pulsed release tablet(PRT) of verapamil.METHODS:The different pulsed release systems were prepared and dissolution tests were conducted to determine the begin time of each PRT.RESULTS:Different dissolution conditions including pH,the basket rotation and viscosity of the dissolution media have almost no influence to the begin time of each PRT.The composition of PRT can change the lag time greatly.CONCLUSION:Effect of dissolution conditions factors can give base on further in vivo study.Lag time of PRT can be freely controlled by change of the composition of PRT.

关 键 词：盐酸维拉帕米 脉冲释放片 时滞 影响因素 

分 类 号：R944.9[医药卫生—药剂学] R972[医药卫生—药学]