对急性白血病患者输注血小板疗效预测  

To predict the effect of platelet transfusion in patients with acute leukemia

作　　者：黄广南[1] 谢德荣[1] 陈岱佳[1] 杨淑英 

机构地区：[1]中山医科大学孙逸仙纪念医院,广州510120

出　　处：《中国航天工业医药》2000年第4期1-2,共2页

摘　　要：目的 建立一个数学模型,对急性白血病患者输注血小板疗效作出预测。方法 采用Logistic多元回归分析及判别分析。结果 Logistic多元回归分析显示输注无效的高危因素包括:患者输血反应次数、使用抗生素、体温及脾大。据高危因素建立的判别函数,总判别符合率为80.9％,有效组符合率为79.4％,错判率为20.6％;无效组判别符合率为82.2％,错判率为17.8％。结论 本判别函数判别符合率高,具有一定的临床应用价值。[Abstract] Objective To establish a mathematical model to predict the effect of platelet transfusion in patients with acute leukemia (AL). Methods 141 cases of AL were studied using the mult if actors logistic regression analysis and discriminant analysis. Results Four factors including the times of blood transfusion reactions in the past, application of the beta-lactam antibiotics in recent one week, fever and enlarged spleen were entered the mul-tifactors logistic regression. Fisher's linear discriminant function was set up using these 4 factors by discriminant analysis. According to this mathematical model, the predicative accuracies of availability, refractoriness to platelet transfusion and the whole were 79.4%, 82.2% and 80.9% . Conclusions The mathematical model of equation was simple, and had good concordance. It was a valuable model in predicting the effect of platlet transfusion.

关 键 词：急性白血病 血小板输注 疗效 预测 

分 类 号：R733.71[医药卫生—肿瘤]