278例药物诱发癫癎分析  

Analysis of 278 Cases of Epilepsy Induced by Drugs

作　　者：杨广声[1] 钱东丽[1] 王领军[1] 

机构地区：[1]河南省新乡医学院第二附属医院,453002

出　　处：《医药导报》2000年第6期597-598,共2页Herald of Medicine

摘　　要：目的 :探讨药物诱发癫的发病因素及可能诱发癫的药物。方法 :收集国内 12 4篇医学期刊上有关药物诱发癫的文献 ,对其临床资料进行综合统计分析。结果 :涉及药品 68种 ,抗精神病药物发病率最高 ,抗生素次之。诱发癫与药物剂量、给药途径、患者年龄、癫病史及家族史等有关。结论Objective:To study the factors of onset of disease about the drug induced epilepsy and the epilepsy inducing drugs. Method:124 domestic literature of drug induced epilepsy were collected, of which the clinical data were synthesized and analyzed. Results:68 drugs were involved, antipsychotics induced incidence was highest, antibiotics next. The induced epilepsy were related to doses of drugs, routes of administration, age of patients, history of epilepsy, and family history. Conclusion:The predisposed patients must take care for selecting drug or selecting the drugs of smaller seizure risk as far as possible.

关 键 词：药源性癫痫 不良反应 抗精神病药 抗生素 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R961[医药卫生—临床医学]