扶正抑瘤法治疗恶性肿瘤的用药策略  

Medicine administration strategy on treating malignant tumor by strengthening body resistance and inhibiting tumor method

作　　者：柯有甫[1] 李春香[2] 高文谦[1] 曾乐谦 魏克民[3] 郑军献[3] 

机构地区：[1]香港大学中医药学院,香港999077 [2]福建医科大学附属第二医院,福建泉州362000 [3]浙江省中医药研究院,浙江杭州310007

出　　处：《中医临床研究》2014年第2期134-135,共2页Clinical Journal Of Chinese Medicine

基　　金：浙江省科技厅基金资助项目(No.2008F3036)

摘　　要：目的:揭示扶正抑瘤法治疗恶性肿瘤的中药用药策略与机理。方法:选取扶正抑瘤法治疗恶性肿瘤的文献,寻找有关药物对恶性肿瘤的用药策略与机理。结果:扶正抑瘤法用药策略:①扶正培本:要根据患者气虚、血虚、阴虚、阳虚、脾虚、肾虚、肺虚、心虚等不同而相应选择补气、补血、补阴、补阳、健脾、补肾、补肺、补心等有抗肿瘤活性的中药;②抑瘤抗癌:要根据患者气滞血瘀、痰湿凝聚、热毒内蕴等不同而相应选择理气行滞、活血化瘀、化痰祛湿、软坚散结、清热解毒、以毒攻毒等有抗肿瘤活性的中药;③扶正与抑瘤要权衡病情轻重缓急;④配合放化疗要重视益气养阴,补气生血,补益脾肾;⑤处方用药追求循证医学证据支持。扶正抑瘤法抗恶性肿瘤的机理:直接细胞毒作用;抑制肿瘤血管生成;抑制细胞外基质的降解;提高机体免疫功能;逆转肿瘤细胞多药耐药;对化疗的减毒增效作用;诱导肿瘤细胞凋亡;诱导肿瘤细胞分化;抑制肿瘤细胞转移等。结论:扶正抑瘤法能早期抑杀肿瘤,减毒增效;中期推迟病情进展,控制转移;后期提高生存质量,延长生存期。Objective： This study aims to reveal medicine administration strategy and mechanism of strengthening body resistance and inhibiting tumor method （SBRITM） for treating malignant tumor. Method： Select the literatures of malignant tumors treated by SBRITM,and look for medicine administration strategy and mechanism of SBRITM for treating malignant tumor. Results： SBRITM Medicine administration strategy： ①Strengthening body resistance and consolidating the constitution（SBRCC）： according to deficiency of Qi, blood, Yin, Yang, spleen, kidney, lung and heart, select TCM medicine with anti-tumor activity in the categories of Tonifying Qi, blood, Yin, Yang, spleen, kidney, lung, heart and so on respectively; ②Inhibiting tumor： according to blood stasis, phlegm coagulation, heat toxin, select TCM medicine with anti-tumor activity in the categories of regulating Qi-flowing for activating stagnancy, promoting blood circulation for removing blood stasis, dispelling phlegm and eliminating dampness, resolving hard lump, clearing away heat and toxic material, using poisons as antidotes and so on accordingly; ③SBRITM need weigh the order of priorities： ④Tonifying Qi and Yin, nourishing Qi and blood, invigorating spleen and kidney with chemotherapy and radiotherapy. ⑤Prescription should support evidence based medicine. SBRITM mechanisms： direct cytotoxicity; inhibition of tumor angiogenesis; inhibition of extracellular matrix degradation; improve immune function; reversal of multidrug resistance of tumor cells; attenuated chemotherapy and synergies; inducing apoptosis; inducing tumor cell differentiation; inhibit tumor cell metastasis. Conclusion： SBRITM can suppress and kill tumors, induce synergism and reduce side effects of chemotherapy or radiotherapy at early stage; SBRITM can slow disease progression, control transfers at mid-term stage; SBRITM can improve the quality of life and prolong survival at later stage.

关 键 词：恶性肿瘤 扶正抑瘤 扶正抗癌 用药策略 机理 

分 类 号：R73[医药卫生—肿瘤]