上前牙固定式树脂平面导板对白细胞介素-1β和白细胞介素-6的影响  

The Impact of Fixed Resin Bite Flat of Maxillary Anterior Teeth on IL-1β and IL-6

作　　者：李瑛[1] 张景慧[1] 钱毅超[1] 赵梦中 张会[1] 

机构地区：[1]包钢医院,内蒙古包头014010 [2]包头市食品药品检验检测中心

出　　处：《包头医学院学报》2013年第6期33-36,共4页Journal of Baotou Medical College

摘　　要：目的:在深覆牙合患者的上前牙区制作前牙固定式树脂平面导板,检测制作导板前后龈沟液量及牙周临床指标的变化,从而推断使用固定式树脂平面导板临床的可行性,为临床应用提供指导。方法:随机选择深覆牙合正畸患者30例,共180颗牙,确定每位患者的实验牙及对照牙,为实验牙制作固定式树脂平面导板,测定不同时期的菌斑指数(plaque index,PLI)、龈沟出血指数(sulcus bleeding index,SBI)、探诊深度(probing depth,PD)、附着丧失(attachment loss,AL),同时提取龈沟液(gingival crevicular fluid,GCF),并测定其体积,采用酶联免疫吸附实验对制作导板前后龈沟液中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)的浓度进行检测。结果:与制作导板前相比较,实验牙在制作平面导板后4周PLI、SBI、PD、GCF、IL-1β、IL-6均增加,差异有统计学意义(P<0.05);实验牙在制作平面导板后4周,与拆除导板后2周相比较,实验牙PLI、SBI、PD、GCF、IL-1β、IL-6均降低,差异有统计学意义(P<0.05);制作平面导板后4周,实验牙与对照牙相比,实验牙的PLI、SBI、PD、GCF、IL-1β、IL-6均增高,差异有统计学意义(P<0.05)。实验牙在制作导板前与拆除导板后相比较,实验牙PLI、SBI、PD、GCF、IL-1β、IL-6均无明显变化(P>0.05);对照牙在制作导板前与制作导板后4周、拆除导板后2周相比较,所有指标均无明显变化(P>0.05)。在佩戴固定式平面导板的过程中,均未检测到AL。结论:通过多因素检测,制作固定式树脂平面导板可使牙龈发生轻微的炎症,但是这种炎症只是暂时的,导板拆除后牙龈可以很快恢复健康,不会对牙周组织造成永久性的损害,应用于临床是可行的。Objective： Fixed resin bite flat was made on maxillary anterior teeth of 30 overbite patients and the clinical indi- ces of gingiva crevicular fluid（ GCF） and periodontium were determined before and after bite plates were made to assess the fea- sibility of clinical application of the fixed resin bite flat for clinical treatment. Methods： 180 maxillary anterior teeth of 30 over- bite patients were selected at random with one side of maxillary anterior teeth selected as experimental teeth and other side select- ed as control teeth. Fixed resin bite flats were made on experimental teeth. Plaque index（ PLI）,sulcus bleeding index（ SBI）, probing depth（ PD） and attachment loss（ AL） were measured at different times. GCF was collected,with its volume measured. ELISA was adopted to determine the concentration of interleukin 1 beta（ IL- 1β） and interleukin 6（ IL- 6） before and after making bite plates. Results： Compared with those of the teeth before making bite flat,the PLI,SBI,PD,GCF IL- 1β,IL- 6 of experiment teeth increased 4 weeks after making bite flat,with significant difference（ P 0. 05）; Compared with those of the teeth two weeks after the removement of the bite flat,the PLI,SBI,PD,GCF IL- 1β,IL- 6 of experiment teeth significantly decreased（ P 0. 05） 4 weeks after making bite flat; Compared with those of the control teeth 4 weeks after making the bite plate,the PLI,SBI,PD,GCF IL- 1β,IL- 6 of experimental group significantly increased（ P 0. 05）. There were no signif- icant differences（ P 0. 05） in PLI,SBI,PD,GCF,IL- 1β,IL- 6 between the experimental teeth before making of bite plate and those after the removement of bite flat. There were no significant differences（ P 0. 05） in all the indicators between the control teeth before making bite plate,those 4 weeks after making of bite plate and those two weeks after the removement of bite plate. AL was not detected during whole experimental process of wearing fixed resin bite flat. Conclusion： The results of

关 键 词：固定式树脂平面导板 龈沟液 白介素-1β 白介素-6 酶联免疫吸附实验 

分 类 号：R783[医药卫生—口腔医学]