阿尔茨海默病患者血浆同型半胱氨酸、叶酸和维生素B_(12)的含量变化  

Change of plasma levels hemocysteine and folate and vitamin B_(12) in patients with Alzheimer's disease

作　　者：李钦云[1] 陈峥[1] 张守字[1] 马丽[1] 张力[1] 武海燕[1] 李文杰[1] 吕继辉[1] 陈楠[2] 何庆生[3] 

机构地区：[1]北京老年医院痴呆科,100095 [2]北京回龙观医院神经生物学研究室 [3]北京老年医院检验科

出　　处：《中华全科医学》2014年第1期9-11,共3页Chinese Journal of General Practice

基　　金：首都医学发展科研基金(2011-2019-01)

摘　　要：目的探讨阿尔茨海默病(AD)患者血浆同型半胱氨酸(Hcy)、叶酸和维生素B12的含量,短期叶酸和维生素B12干预AD患者后,观察血浆Hcy的含量变化,以及认知功能和日常生活能力的改变。方法入组AD患者126例,进行基线MMSE和ADL的评定;正常对照组120例。空腹采取静脉血3 ml,离心后取血浆测定Hcy、叶酸和维生素B12浓度。AD组给予叶酸和维生素B12干预4周,再进行血浆Hcy和MMSE及ADL的评定。结果 AD组血浆Hcy、叶酸和维生素B12分别是(18.69±4.57)μmol/L、(10.86±3.96)nmol/L、(266.62±42.38)pmol/L;正常对照组分别是(10.23±2.85)μmol/L、(15.92±4.45)nmol/L、(335.90±95.58)pmol/L。AD组血浆Hcy高于正常对照组,差异有统计学意义(P<0.05),而叶酸和维生素B12低于正常对照组,差异有统计学意义(P<0.05)。叶酸5 mg(3次/d)和维生素B12500 mg(1次/d)干预AD组4周后,血浆Hcy水平显示差异有统计学意义(P<0.05),而MMSE、ADL治疗前后比较差异无统计学意义(P>0.05)。结论 AD患者血浆中Hcy显著升高,而叶酸和维生素B12显著下降,叶酸和维生素B12短期干预AD患者没能显示改善认知功能和日常生活能力的改善。Objective To investigate content of plasma levels of hemocysteine and folate and vitamin B12 in patients with Alzheimer＇ s disease;after short-time intervention with folate and vitamin B12,then assay plasma levels hemocysteine and mini-mental state examination（MMSE） and Activity of Daily Living Scale（ADL） with Alzheimer＇ s disease. Methods 126 AD patients were evaluated MMSE and ADL at baseline;120 persons were set as normal control. Content of plasma levels of hemocysteine and folate and vitamin B12 in 3 ml of venous blood sample from 126 AD patients and 120 normal controls were examined. After interfering with folate and vitamin B12 for 4 weeks to AD patients,then assay plasma levels hemocysteine and MMSE and ADL with Alzheimer＇ s disease. Results Plasma levels of Hemocysteine （ 18.69 ± 4.57 ） nmoL/L and folate （ lO. 86 ± 3.96） nmol/L and vitamin B12 （266.62 ± 42.38 ） pmol/L in patients with Alzheimer＇ s dis- ease were significantly different from normal controls [ Hemocysteine （ 10.23 ± 2.85 ） μmol/L, folate （ 15.92 ± 4.45 ） nmol/L,vitamin B12 （335.9 ± 95.58）pmnl/L（ P 〈 0.05 ） ]. There was ,t significant difference after interfering with folate 5 mg three times a day and vitamin B12 500 mg one time a day for 4 weeks to AD patients（P 〉0.05）with MMSE and ADL,but plasma levels hemocysteine was significantly different between two groups （P 〈 0. 05 ）. Conclusion Plasma levels of Hemocysteine in patients with Alzheimer＇ s disease was significant elevated than normal controls;but folate and vitamin B 12 was significantly decreased in patients with Alzheimer＇ s disease;there was, t significant difference after inter- fering with folate and vitamin B12 for 4 weeks in AD patients with MMSE and ADL.

关 键 词：阿尔茨海默病 同型半胱氨酸 叶酸 维生素B12 VITAMIN B12 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]