应用TRFIA在31万余新生儿中筛查先天性甲状腺功能低下症  

315472 Neonatal screening for Congenital Hypothyroidism with Time-resolved Fluorescence Immunoassay

作　　者：田国力[1] 董庆元[1] 朱伟明[1] 曹其缃[1] 

机构地区：[1]上海市儿童医院新生儿筛查中心,上海200040

出　　处：《上海医学检验杂志》2000年第6期353-354,共2页Shanghai Journal of Medical Laboratory Sciences

摘　　要：目的开展新生儿先天性甲状腺功能低下症 (CH )筛查 ,降低残疾儿童的发生率 ,提高我国人口素质。方法应用先进的时间分辨荧光免疫法 TRFIA检测新生儿促甲状腺素的浓度筛查 CH。结果筛查新生儿 CH315 472名 ,确诊 6 6例 ,筛查阳性率为 1/4 780。结论应用 TRFIA筛查 CH,是理想的非放射性免疫分析法。接受国际和国内新生儿筛查实验室质量监控 ,是对大批量筛查标本质量的有效保证。选用该法筛查 CH能逐渐适宜于我国经济实力不断发展的国情。Objective To develop the newforn screening for congenital hypothyroidigm(CH),can prevent the childrem from mental retardation and improve the eugenics of our country. Methods thyroid stimulating hormone (TSH) value was detected with time resolved fluorescence immunoassay (TRFIA).Results 315472 neonates were screened for CH, 66 cases were confirmed, the incidence was 1/4780. Conclusion Using TRFIA for screening CH is suitable to the condition of our country.

关 键 词：新生儿疾病筛查 时间分辨荧光免疫法 先天性甲状腺功能低下症 促甲状腺素质量控制 

分 类 号：R581.204[医药卫生—内分泌] R446.61[医药卫生—内科学]