靶向调节性T细胞的肿瘤免疫治疗的研究进展  

The therapies targeting regulatory T cells

作　　者：董天秀[1] 任欢[2] 杨秀华[1] 

机构地区：[1]哈尔滨医科大学附属第一医院腹部超声科,150001 [2]哈尔滨医科大学免疫教研室

出　　处：《国际免疫学杂志》2014年第1期6-9,共4页International Journal of Immunology

基　　金：国家自然科学基金面上项目（81171346）;黑龙江省教育厅科学技术研究面上项目（12511327）

摘　　要：免疫系统通过固有和适应性免疫监督来防止肿瘤的发生、进展，但是仍然有肿瘤细胞逃脱免疫网络的监视，在体内大量繁殖，调节性T细胞（Treg）就是帮助肿瘤细胞逃脱的原因之一，所以靶向Treg的治疗是肿瘤免疫治疗的关键。了解Treg上的各种功能分子及其作用，Treg的来源以及转化方式，对阐明其调控靶点，进而概述靶向Treg的治疗方式很有意义。The immune system prevents organism from the occurrence and progress of tumor drawing assistance from innate and adaptive immune smweillance . However, some tumor cells could escape from the mo- nitoring of immune network , and bloom in the body. Regulatory T cells plays a vital role during this progression, therefore, the therapies targeting regulatory T cells is the key point of tumor immunotherapy. In order to find some therapeutic target spots ,we analyzed the role of various functional molecules of the regulatory T cells, the origin of regulatory T cells and its transformation . In conclusion, we summarized several therapies targeting ＇regulatory T cells which could inhibit the malignant progression of tumor.

关 键 词：调节性T细胞 肿瘤 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]