盐酸美利曲辛合成工艺研究  

Research on the Synthesis Process of Melitracen Hydrochloride

作　　者：张立颖[1] 刘旭亮[2] 孟庆荣[2] 

机构地区：[1]山东理工大学,山东淄博255049 [2]山东新华制药股份有限公司,山东淄博255086

出　　处：《山东化工》2013年第12期7-8,共2页Shandong Chemical Industry

摘　　要：本文对盐酸美利曲辛合成工艺进行了优化研究。以10,10-二甲基蒽酮为起始原料,经格式反应缩合及成盐而得盐酸美利曲辛成品,非水滴定法检测纯度高于99.8%,总收率大于65.0%。The paper was aimed to study the synthetic process of melitracen hydrochloride. It ~ prepared with 10,10 -dimethylanthrone as starting material through Grignard reaction, which was subject to salt formation. The average yield of melitracen hydrochloride was more than 65.0% with a purity of 99.8%.

关 键 词：盐酸美利曲辛 10 10-二甲基蒽酮 合成 

分 类 号：TQ463[化学工程—制药化工]