乳腺浸润性导管癌中ATAD2的表达及其临床意义  

Expression of ATAD2 and its clinical significance in invasive mammary ductal carcinoma

作　　者：果海娜[1] 李良[1] 黄锦叶[1] 王娜[1] 陈昌伟[1] 何江耀 

机构地区：[1]中山大学附属东莞东华医院病理科,东莞523100

出　　处：《临床与实验病理学杂志》2014年第1期15-18,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：广东省东莞市科技计划(201110515046227)

摘　　要：目的探讨乳腺浸润性导管癌组织中ATAD2、c-MYC和ER的表达及其相互之间的关系。方法釆用免疫组化EnVision两步法检测110例乳腺浸润性导管癌中ATAD2、c-MYC、ER、PR、HER-2、CK5/6、EGFR的表达,以及77例癌旁正常组织中ATAD2的表达。结果 ATAD2在乳腺浸润性导管癌组织中的阳性率明显高于癌旁组织,二者差异有统计学意义(P<0.05);乳腺浸润性导管癌中ATAD2表达与乳腺癌的组织学分级、基因分型(尤其basal-like亚型)、淋巴结转移有相关性(P<0.05);与c-MYC有明显正相关性;ATAD2表达与ER、患者年龄、肿块大小无明显相关性(P>0.05)。结论 ATAD2在乳腺浸润性导管癌的发生、发展中起重要作用,是预测乳腺浸润性导管癌生物学行为的指标之一,并有望成为乳腺浸润性导管癌尤其basallike亚型治疗的新靶点。Purpose To investigate the expression and significance of ATAD2, c-MYC, ER in breast invasive ductal carcinoma, and to analysis the relationship between ATAD2, c-MYC and ER. Methods The expression of ATAD2, e-MYC, ER, PR, HER-2, CK5/6 and EGFR was detected by immunohistochemieal EnVision in 110 cases of breast invasive ductal carcinoma and 77 cases of ad- jacent normal breast tissue. Results Higher positive rate of ATAD2 was obtained in invasive duetal carcinoma compared to adjacent normal tissue, and the difference was significant （P 〈 0.05）. The expression of ATAD2 was correlated with tumor histologic grades, basal-like subtype, lymph-node metastasis （ P 〈 0.05 ）. There was significantly positive association between the expression of ATAD2 and c-MYC expression. However, the expression of ATAD2 was not significantly correlated with the expression of ER, age of patients and the size of tumor （P 〉 0. 05 ）. Conclusions ATAD2 may play an important role in the carcinogenesis and development of breast invasive ductal carcinoma. ATAD2 may serve as a new biological behavior and targeting treatment for patients with invasive mammary duetal carcinoma, especially for the basal-like type.

关 键 词：乳腺肿瘤 ATAD2 临床病理学 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]