脑梗死急性期相关生化指标与早期临床转归的关系  

Relation of the associated biomarkers and the early clinical outcomes in acute cerebral infarction

作　　者：孙静[1] 姚源蓉[1] 程焱[1] 

机构地区：[1]天津医科大学总医院神经内科,300052

出　　处：《实用医学杂志》2014年第3期393-396,共4页The Journal of Practical Medicine

摘　　要：目的:探讨脑梗死急性期相关生化指标与早期临床转归的关系。方法:选首次发病317例脑梗死患者,于发病24 h内行凝血功能、肝功能、血脂、肾功能、电解质等检查,入院即刻行中国卒中量表(Chinese Stroke Scale,CSS)评分、美国国立卫生研究院(NIH Stroke Scale,NIHSS)评分,入院后第10天行NIHSS评分。按CSS评分分为轻、中、重型3组,按入院即刻与入院后第10天的NIHSS评分差值分为好转组、无变化组和恶化组,比较各组间相关指标的差异。结果:轻中重3型患者的血钙(SC)、总胆红素(TBIL)、纤维蛋白原(FIB)、同型半胱氨酸(HCY)、血尿酸(SUA)水平比较差异有统计学意义(P<0.05),随病情加重,SC呈降低趋势,TBIL、FIB、HCY、SUA水平呈增高趋势;临床转归不同组间的SC、FIB、SUA值差异均有统计学意义(P<0.05),恶化组的SC最低,FIB、SUA水平最高。结论 :脑梗死患者急性期SC、FIB、SUA水平与病情轻重及临床转归有密切关系,TBIL、HCY与病情轻重有关联。Objective To investigate the relation of the associated biomarkers and the early clinical outcomes in acute cerebral infarction. Methods Three hundred and seventeen patients with cerebral infarction were enrolled after the first onset. Coagulation function, liver, kidney function, blood cholesterol, and electrolytical were tested within 24 hours of onset. Chinese Stroke Scale （CSS） and National Institutes of Health Stroke Scale （NHISS） were scored on admission, and NHISS on the tenth day after admission were scored. Evaluated the severity on admission and early functional recovery on the tenth day after admission with CSS and the difference of NHISS. According to CSS, patients were divided into three groups： mild, moderate and severe group. According to scale margin of NHISS between on admission and the tenth day after admission, patients were divided into three groups： improved group, unchanged group and worsened group. Difference of biomark^rs among different groups were statistical analyzed. Results Serum calcium （SC）, TBIL, FIB, HCY, SUA le~,els among mild, moderate and severe group were significantly different （P 〈 0.05）. The more severe, the higher TBIL, FIB, HCY, SUA levels and the lower SC level. The SC, FIB, SUA levels were significantly different among improved group, unchanged group and worsened group （P 〈 0.05）. SC level were the lowest in worsened group, while FIB, SUA levels were the highest. Conclusions In acute cerebral infarction patients, SC, FIB, SUA levels are closely related to the severity and early clinical prognosis.

关 键 词：脑梗死 生化指标 早期临床转归 

分 类 号：R743.3[医药卫生—神经病学与精神病学]