调气止泻方预防氟尿嘧啶类化疗相关性腹泻的临床研究  

Clinical observation of regulating qi and stopping diarrhea formule on preventing diarrhea induced by fluorouracil chemotherapy

作　　者：李柳宁[1] 明亮[2] 逯敏[1] 柴小姝[1] 张力文[1] 刘柏[1] 陈志坚[1] 何春霞[1] 洪宏喜[1] 

机构地区：[1]广东省中医院肿瘤内科,广州市510000 [2]广州中医药大学第二临床医学院,2009级硕士510405

出　　处：《实用医学杂志》2014年第3期480-483,共4页The Journal of Practical Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金(编号:320.6750.1225)

摘　　要：目的:观察调气止泻方在应用含氟尿嘧啶类化疗方案时对化疗相关性腹泻(CID)的预防作用。方法:采用前瞻性非随机对照研究方法,选择符合纳入标准的胃肠道恶性肿瘤住院患者按治疗方案分为调气止泻方干预组和空白对照组,以CID发生率及发生CID等级、主要症状、卡氏评分作为衡量疗效的指标,对调气止泻方预防CID的效果做出临床评估。结果:共纳入合格病例81例,其中试验组40例,空白对照组41例。(1)第1次化疗后,试验组CID发生率为25.0%,对照组CID发生率为46.3%,两组间差异没有统计学意义(P>0.05);第2次化疗后,试验组CID发生率为15.0%,对照组CID发生率为73.2%,两组间差异有统计学意义(P<0.05)。(2)两组在试验前后症候评分情况:试验组症候疗效评价进步15例(37.5%),对照组症候疗效评价进步1例(2.4%),两组间差异有统计学意义(P<0.05)。(3)两组在试验前后卡氏评分方面:试验组降低1例(2.5%),稳定32例(80.0%),提高7例(17.5%);对照组降低7例(17.1%),稳定29例(70.0%),提高5例(12.2%)。结论:调气止泻方可预防CID发生,对改善临床症状和KPS评分也有一定作用。Objective To observe the prevention of regulating qi and stopping diarrhea formule on the fluorouracil （5-FU, Xeloda, etc.） chemotherapy-related diarrhea （CID）. Methods Adopt the study method on prospective, non-randomized and controlled. Inpatients diagnosed gastrointestihal malignancy according to the inclusion criteria, were selected and divided into experimental groups and control groups by treatment programs. 81 cases were brought into the program, including 40 cases in experimental group, 41 cases in control group. Incidence of CID, the occurrence of CID grade, the main symptoms, Karnofsky performance status were measured as efficacy indicators. Then we analyzed the role of regulating qi and stopping diarrhea formule in the reduction of chemotherapy poison. Results （1） CID situation occurs： after the first chemotherapy, the CID incidence of the experimental group was 25.0%, and that in the control group was 46.3%. There was no significant difference between two groups （P 〉 0.05）. After the second chemotherapy, CID incidence of the experimental group was 15.0%, while the control group＇s was 73.2%. There was significant diffetionce between two groups （P 〈 0.05）. （2） Symptom scores situation： symptom scores progress incidence of the test group was 37.5%, the control group＇s was 2.4%, and there was significant difference between two groups （P 〈 0.05）. （3）Kamofsky performance： the performance of the test group Kamofsky reduced 1 （2.5%） , stable 32（80.0%）, increased 7（17.5%） ; decreased 7（17.1%） control group, stable 29 （70.0%）, increased 5 （12.2%）. Conclusions Regulating qi and stopping diarrhea formule plays a role in the prevention of CID and in improving the clinical symptoms of TCM and KPS scores.

关 键 词：氟尿嘧啶 胃肠道恶性肿瘤 调气止泻方 化疗相关性腹泻 

分 类 号：R730.6[医药卫生—肿瘤]