诊断分化型甲状腺癌复发和转移的方法学比较  

Diagnostic Value of Serum Thyroglobulin, Diagnostic ^(131)Ⅰ Whole-body Scan and Neck Ultrasonography for Evaluation of Lymph Node Metastasis and Recurrence of Differentiated Thyroid Cancer

作　　者：倪剑[1,2] 吴瑕[1] 潘明志[1] 黄蕤[1] 唐恭顺[1] 

机构地区：[1]四川大学华西医院核医学科,成都610041 [2]简阳市人民医院核医学科

出　　处：《华西医学》2014年第1期34-38,共5页West China Medical Journal

基　　金：国家自然科学基金(30970859)~~

摘　　要：目的分析血清甲状腺球蛋白、诊断剂量的全身碘131(131I)显像(D-WBS)、颈部超声诊断分化型甲状腺癌(DTC)转移、复发的效能。方法回顾性收集2011年5月-6月四川大学华西医院甲状腺全切术、131I去除治疗后6个月或以上DTC随访患者50例。以临床综合诊断作为参考标准绘制四格表研究这些方法的诊断效能。结果免疫分析法血清Tg值(TgIMA)与D-WBS平行实验诊断DTC转移、复发的灵敏度、特异度、准确性、阳性预测值、阴性预测值分别是100.0%、92.9%、96.0%、91.7%、100.0%。结论在比较的几种方法中,TgIMA结合D-WBS平行试验诊断DTC转移、复发的准确性最高。Objective To compare the diagnostic efficacy of serum thyroglobulin （Tg）, diagnostic ^131I whole- body scan （D-WBS）, neck ultrasound for diagnosing metastasis and recurrence of differentiated thyroid carcinoma （DTC）. Methods From May to June 2011, fifty follow-up DTC patients were collected retrospectively 6 months or more after ^131I ablation therapy following total-thyroidectomy or near-total thyroidectomy. The diagnostic standard for DTC metastasis and relapse were based on serum Tg, D-WBS, neck ultrasound and chest CT. Diagnostic 2 by 2 table was employed for calculating the sensitivity, specificity, accuracy of the methods. Results The sensitivity, specificity, accuracy, positive predictive value, negative predictive value of TgIMA and D-WBS parallel experiments were 100.0%, 92.9%, 96.0%, 91.7%, and 100.0% respectively. Conclusion TgIMA combined with D-WBS parallel test in diagnosis of DTC metastasis and recurrence has the highest accuracy.

关 键 词：甲状腺癌 甲状腺球蛋白 碘131全身显像 

分 类 号：R736.1[医药卫生—肿瘤]