YAP蛋白与肿瘤  

Relationship between YAP protein and tumor

作　　者：蒋宁[1] 顾恺[1] 牛远杰[1] 

机构地区：[1]天津医科大学第二医院天津市泌尿外科研究所,天津300211

出　　处：《基础医学与临床》2014年第2期262-265,共4页Basic and Clinical Medicine

基　　金：国家"973"课题(2012CB518304);天津市科技计划项目(11JCZDJC19700;09ZCZDSF04300)

摘　　要：Hippo-YAP信号通路是新发现的生长控制信号通路,能够限制调结细胞的生长增殖,细胞凋亡,信号通路异常有利于肿瘤的发生。YAP蛋白还参与调控AKT-mTORC、WNT和MAPK等信号通路,进而影响肿瘤细胞的生长和侵润转移。YAP蛋白在多种类型的人类肿瘤中表达异常增加,或许成为肿瘤新的治疗靶点。The Hippo-YAP pathway is a newly growth regulatory pathway and regulate both cell growth and apop- tosis, aberrant signaling pathway contribute to tumorigenesis. YAP protein is also involved in the mediate AKT-mTORC, WNT and MAPK signaling sis. YAP protein expression is increased in pathways, thereby affecting tumor cell growth, invasion and metasta- many types of human tumors, perhaps to become new therapeutic tar-gets of tumor.

关 键 词：YAP蛋白 信号通路 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]