视觉P300电位在精神分裂症司法鉴定责任能力评定中的初步应用  

Preliminary study on application of visual P300 potentials in responsible appreciation of schizophrenia patients by judicial expertise

作　　者：韩慧琴 谢斌[1] 穆俊林[2] 杨晓敏 张明岛[1] 楼翡璎[1] 梁建华[1] 陈冲[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]河南省精神病医院,郑州453002

出　　处：《上海交通大学学报（医学版）》2014年第1期53-55,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市精神卫生中心院级课题(2011-YJ-09);科技部"十二五"科技支撑计划(2012BAK16B04);国家自然科学基金青年项目(81202388)~~

摘　　要：目的探讨视觉P300在精神分裂症司法鉴定责任能力评定中的价值。方法分别对经司法鉴定为无责任能力的精神分裂症患者(n=68,无责任能力组)和限定责任能力的精神分裂症患者(n=59,限定责任能力组)进行视觉司法事件相关脑电位P300检测,以58名志愿受试者作为对照(正常组)。结果与正常组比较,无责任能力组和限定责任能力组P300电位成分中N1、N2和P3潜伏期显著延长(P<0.01),P3波幅显著降低(P<0.01)。无责任能力组P300电位成分中N1、N2和P3潜伏期较限定责任能力组显著延长,P3波幅则显著降低,组间比较差异均有统计学意义(P<0.01)。结论视觉P300在精神分裂症司法鉴定责任能力评定中有一定的参考意义,但研究结果还有待进一步随访验证。Objective To explore the value of visual P300 potentials in responsible appreciation of schizophrenia patients by judicial expertise. Methods Sixty-eight schizophrenia patients without responsible ability （group A） and 59 schizophrenia patients with limited responsible ability （group B） by judicial expertise and 58 healthy volunteers （ group C） were enrolled in this study. They were given visual P300 potentials test. Results Compared to group C, latent periods of N1, N2, and P3 of P300 in groups A and B were significantly longer （P 〈 0.01）, and the amplitude of P3 decreased markedly （P 〈 0.01）. Compared to group B, latent periods of N1, N2, and P3 of P300 in group A were significantly longer, and amplitude of P3 decreased markedly （P 〈 0. 01）. Conclusion Visual P300 potentials test has referential meaning in responsible appreciation of schizophrenia by judicial expertise, which needs confirmation by long follow-up.

关 键 词：司法鉴定 责任能力 精神分裂症 视觉P300电位 

分 类 号：R749.3[医药卫生—神经病学与精神病学]