慢性炎症对肿瘤干细胞的调控  

Chronic Inflammation and Cancer Stem Cells

作　　者：陈翀[1] 罗云萍[1] 

机构地区：[1]中国医学科学院基础医学研究所,北京100005

出　　处：《生物化学与生物物理进展》2014年第1期52-57,共6页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)资助项目(2013CB967202)~~

摘　　要：大量研究已证实肿瘤干细胞是肿瘤耐药、复发和转移的根源.慢性炎症与肿瘤的发生和发展密切相关,肿瘤炎性微环境中的IL-6、IL-8、EGF等炎性因子和生长因子激活了肿瘤干细胞内NF-κB/Stat3信号通路,维持肿瘤干细胞的自我更新能力,从而促进肿瘤的生长和转移.深入研究肿瘤炎性微环境对肿瘤干细胞的调控机制,可以使我们找到潜在的治疗靶点,为攻克肿瘤带来新的思路和手段.Abstract Cancer stem cells have been suggested to play key role in tumor relapse, drug-resistance and metastasis. Chronic inflammatory states have been associated with an increased risk of malignancy. Therefore, it is possible that cytokines associated with chronic inflammation, such as IL-6, IL-8 and EGF, regulate the self-renewal of cancer stem cells via NF-KB/ Stat3 pathways. In this review, we will discuss how these adaptive processes potentially become subverted to enhance the development and function of cancer stem ceils.

关 键 词：肿瘤干细胞 肿瘤炎性微环境 NF—KB STAT3 

分 类 号：R730.3[医药卫生—肿瘤]