血清半乳糖凝集素-3水平与原发性胆汁性肝硬化的相关性分析  

Correlation analysis of serum galectin-3 levels with primary biliary cirrhosis

作　　者：张榕[1] 郝丽敏[2] 宋良月[1] 左大辰 肖卫国[1] 

机构地区：[1]中国医科大学附属第一医院风湿免疫科,沈阳110001 [2]山西医科大学附属第二医院风湿免疫科

出　　处：《中华风湿病学杂志》2014年第1期45-47,共3页Chinese Journal of Rheumatology

基　　金：基金项目：辽宁省科技厅科学技术计划项目（2012225097）;中国医科大学附属第一医院院级课题（fsfh1212）

摘　　要：目的探讨半乳糖凝集素．3（Gal-3）在PBC发病机制中的作用。方法比较72例不同病期PBC患者的临床指标，应用ELISA检测72例PBC患者及20名健康对照者Gal-3血清水平。采用t检验、方差分析、LSD．t检验与Pearson相关分析进行统计学分析。结果PBC患者血清Gal-3水平高于健康对照组[（855＋634）pg／ml与（463±446）pg／ml，P〈0．05]，此外，随着病情进展PBC患者Gal-3水平、血小板、血红蛋白、白蛋白、IgM及补体c3水平逐渐降低，总胆红素水平升高（P〈0．05），PBC患者Gal-3水平与IgM及补体C3呈正相关（r=-0．330，P=0．005；r=0．357，P=0．002），与总胆红素呈负相关（r=0．350，P=0．003）。结论Gal-3可能参与PBC的免疫炎症损伤及肝纤维化的形成，Gal-3、血小板、血红蛋白、白蛋白、IgM、补体c3及总胆红素水平可作为判断病情轻重的指标。Objective To investigate the effect of galectin-3 （Gal-3） on the pathogenesis of primary biliary cirrhosis （PBC）. Methods The clinic data of 72 PBC patients at different stages were analyzed and the serum levels of Gal-3 were detected in 72 PBC patients and 20 controls by enzyme linked immunosorbent assay （ELISA）. Independent t-test, variance analysis, LSD-t and Pearson correlation analysis were adopted for data analysis. Results The serum Gal-3 levels were significantly higher in PBC patients than those of healthy controls [ （855±634） pg/ml, （463±446） pg/ml, P〈0.05 ]. With the progression of disease, the levels of Gal-3, platelets, hemoglobin, albumin, IgM and complement C3 gradually declined, but the level of total bilirubin gradually elevated（P〈0.05 ）. There was positive correlation between Gal-3 and immunoglobin IgM, complement C3 levels （r-0.330, P=0.005; r=0.357, P=0.002）. There was negative correlation between Gal-3 and total bilirubin levels （r=-0.350, P=0.003）. Conclusion The Gal-3 can participate in the immune-mediated infl- ammation of PBC and the formation of liver fibrosis. The levels of Gal-3, platelet count, hemoglobin, albumin, IgM, complement C3 and total bilirubin could be regarded as laboratory parameters for the evaluation of the disease severity and prognosis.

关 键 词：肝硬化 胆汁性 半乳糖凝集素3 

分 类 号：R575.2[医药卫生—消化系统]