海糖平改善小鼠脂质代谢紊乱作用研究  

Effect of Haitangping on Dyslipidaemia in Mouse Induced by Feeding High-Fat Diet

作　　者：孟薇薇[1] 赵海伟[1] 吴崇明[2] 林凡凯[1] 郭楠[1] 邓玉林[1] 戴荣继[1] 陈艳 

机构地区：[1]北京理工大学生命学院,北京100081 [2]中国医学科学院药用植物研究所,北京100193 [3]北京理工亘元医药技术开发中心有限公司,北京100081

出　　处：《北京理工大学学报》2013年第12期1317-1320,共4页Transactions of Beijing Institute of Technology

摘　　要：研究射干茎叶提取物-海糖平(HTP)对高脂饲料诱导的小鼠脂代谢紊乱的改善作用.ICR小鼠连续12周高脂饲料喂养诱发脂质代谢紊乱.造模成功后分别灌胃给予海糖平50,100,200mg/kg BW,治疗4周,并以吉非罗齐胶囊(100mg/kg BW)作为阳性对照药.治疗结束后检测肝脏和血清中甘油三酯(TG)、总胆固醇(TC)含量,附睾脂肪组织重量等指标,同时做肝脏组织病理检查.结果显示海糖平能够降低肝脏中TG、TC水平及血清中TG水平,减轻附睾脂肪组织重量,减少肝细胞中脂滴的蓄积.证实海糖平具有改善高脂饲料喂养小鼠的血清和肝脏中脂质代谢紊乱的作用.The improved effects of Haitangping （HTP） extracted from steams and leaves of blackberry lily on the high-fat diet-induced disorder of lipid metabolism were studied. Disorder of lipid metabolism was induced in ICR mouse by feeding them a high-fat diet for 12 weeks. After oral administration of HTP （50,100,200 mg/kg BW） and the positive control drug gemfibrozil capsules （100 mg/kg BW） for 4 weeks, the triglycerides and total cholesterol in liver and blood serum were examined. Meanwhile, the weight of adipose tissue in epididymis and did pathological examination of liver tissue was examined. The results show that HTP lowered triglyceride and total cholesterol levels in liver, decrease the level of triglyceride in blood serum, reduce the weight of adipose tissue in epididymis, and cut down the accumulation of the lipid droplet in hepatic cell. Those results demonstrate that the oral administration of HTP prevents the progress of lipid metabolism disorders in liver and blood serum while feeding the mouse with high-fat diet.

关 键 词：海糖平 脂代谢紊乱 高脂饲料 甘油三酯 总胆固醇 

分 类 号：R734.2[医药卫生—肿瘤] R961.1[医药卫生—临床医学]